Published today  in the journal , the study provides a major insight into the muscular dystrophy subtype known collectively as Collagen VI-related dystrophy – or COL6-RD for short.

The team are the first ever to determine the high resolution structure of collagen VI- one of the networks of protein molecules that give our tissues mechanical strength and the ability to stretch and bend.

Called the extracellular matrix, the protein network also enables cells to sense their environment and communicate with one another in response to mechanical forces.

COL6-RD, which includes Ullrich congenital muscular dystrophy (UCMD) and  Bethlem myopathy (BM), can cause a range of symptoms including muscle weakness, joint contractures, decreased muscle tone, and weak breathing muscles.

It is one of a number muscular dystrophy subtypes and others include the more prevalent Duchenne-  caused by mutation of another protein -   for which scientists are developing gene therapies.

However, so far equivalent therapies have not been developed for COL6-RD.

Collagens are the most abundant extracellular matrix proteins, and form long fibres many times smaller than a human hair, called microfibrils. 

Collagen VI forms one type of microfibril, taking on the appearance of a large bead-like structure, consisting of  three separate protein chains, that twist and fold together.

The research required the scientists to develop small fragments of collagen VI, which they called mini-collagens.

Mini-collagens will be useful tools for studying or even treating the diseases associated with collagen VI mutations.

Lead author of Biotechnology and Biological Sciences Research Council funded study Clair Baldock, Professor of  Biochemistry at the University of Manchester said: “It is extremely important to understand where mutations in the tiny protein chains called collagen VI that cause a subtype of muscular dystrophy are, to help in the design of future treatments.

“Using a technique called cryogenic-electron microscopy -  which can magnify collagen VI hundreds of thousands of times-   we were able to determine the organisation of parts of collagen VI and map the disease mutations.

“That provides an opportunity for scientists to design drugs which specifically target the mutations by focusing only on what's broken.

She added: “We are the first group to determine the high resolution structure of collagen VI; until now, no- one has been able to show the locations of these mutations on the collagen VI structure.

“This is an important step along the path of finding ways to treat these types of muscular dystrophy and will provide momentum  to accelerate scientific discovery in this area.

“We hope that our structure will provide vital information to help the scientific community develop treatments, such as gene therapy, for collagen VI-RD.

“This provides some hope to people with muscular dystrophy that one day treatments will be available to improve their quality of life and help them to stay active and independent.”

• The paper Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations is . https://doi.org/10.1038/s41467-025-62923-3

Jean, alongside her late husband Michael, co-founded the Oglesby Charitable Trust in 1992, building a legacy that has touched thousands of lives across the North West and beyond. The University has been privileged to share in that legacy for many decades. Jean’s approach to philanthropy was deeply personal – she wanted to understand the programmes she supported, meet the people leading them, and be certain that her giving would create lasting change.  

Through the Trust, Jean and Michael made transformational contributions to our work – from funding PhD scholarships at the Wolfson Molecular Imaging Centre to advancing pioneering research in cancer and leukaemia, to supporting public health policy and environmental sustainability initiatives. Their leadership and generosity were instrumental in establishing the Manchester Cancer Research Centre’s new home, where world-leading oncology teams are now working to develop personalised cancer treatments that will save and extend lives.   

Jean also enriched the University’s cultural life. Her love of the arts was expressed through the Trust’s support for Manchester Museum initially for the vivarium and followed by support for wider capital projects. This was also demonstrated in the Trust’s commissioning of original artworks for the Martin Harris Centre for Music and Drama, the John Rylands Library, and the Whitworth Art Gallery. These contributions have enhanced our campus as a place to learn, work and be inspired. 

In 2015, Jean and Michael became two of the founding members of the Langworthy Circle of Benefactors, an honour that acknowledges our most significant donors. In 2016, Jean was also honoured with a CBE for services to philanthropy in the North West. But those who knew her will remember her most for her warmth, wisdom, and quiet strength - qualities that left an impression on everyone she met.  

Professor Duncan Ivison, President and Vice-Chancellor, said:  “Jean was a close friend to the University and a force for good. Her compassion and clarity of purpose were extraordinary. She believed deeply in the power of community.  She touched and inspired countless lives – in Manchester and far beyond. Her legacy will live on through the Oglesby Charitable Trust, the causes she championed, the institutions she supported and the communities she cared for so deeply.”  

On behalf of the entire University community, we offer our heartfelt condolences to Jean’s family and friends, and our enduring gratitude for her extraordinary partnership, which will continue to inspire for generations to come. 

“For an institution of our scale and ambition, continued progress on the global stage is both a challenge and an opportunity," Duncan added.

The 2025 ARWU result follows a strong year for Manchester in other leading global rankings - in June, it was named the 35th best university in the world in the QS World University Rankings.

The power of the University’s social and environmental impact has also been recognised on a global scale, being the only university in the top ten in both the QS World University Sustainability Rankings and Times Higher Education Impact Rankings, in recognition of its contribution towards the United Nations’ Sustainable Development Goals (SDGs).

The University’s research strength is further evidenced by the 2021 Research Excellence Framework (REF), in which 93% of research activity was rated either ‘world-leading’ (4*) or ‘internationally excellent’ (3*).

“Manchester has always been a place where world-class research meets real-world impact,” said Vice-President for Research Professor Colette Fagan. “We are proud of our achievements, but even more excited about what lies ahead.”

The full 2025 ARWU list and methodology can be explored at ShanghaiRanking’s .

 Published in the American Journal of Nephrology today (11/08/25), the researchers show that higher levels of  Kidney Injury Molecule-1(KIM-1), a special marker of kidney damage in the blood and urine, are associated with higher risks of mortality and kidney failure, never before have the two been measured together. 

The research follows hot on the heels of their published in the Journal of the American Society of Nephrology last month, which measured 21 markers in blood and urine that reflect key processes driving kidney disease, inflammation, and heart disease. 

From the JASN study , the team pinpointed three standout markers that can predict both how quickly kidney disease will progress and the risk of death. 

Unlike the generic tests used in routine kidney clinics, the markers shine a light on the biological changes, underpinning CKD, that truly drive the disease. By revealing the hidden drivers, the discovery opens the door to new treatments designed to target the disease at its roots. 

Lead author Dr Thomas McDonnell, is both a researcher at The University of Manchester and a kidney doctor at Salford Royal Hospital, part of Northern Care Alliance NHS Foundation Trust. 

He said: “The progression of chronic kidney disease is highly variable between people,  so it’s difficult to predict which patients will progress to kidney failure or worse. 

“But our work raises the prospect of the development of  simple blood or urine tests that could better predict the degree of risk-  invaluable information for doctors and patients. 

“We think that , these models, which are more closely aligned with the underlying biological changes happening in chronic kidney disease, could allow a more tailored approach to the individual needs of patients.”

The researchers analysed the blood and urine of adults with non-dialysis chronic kidney disease from 16 nephrology centres across the UK.

They analysed blood and urine KIM-1 in 2581 patients for the KIM-1 study and looked at all 21 markers of kidney damage, fibrosis, inflammation, and cardiovascular disease together in 2,884 patients for the second

They used statistical analysis  to assess how or if biological signals associated with kidney failure and mortality, and developed risk prediction models.

Because chronic kidney disease can stay stable for years in one person but suddenly worsen in another, doctors find it difficult to identify which patients are most at risk.

Existing blood tests currently only give doctors a partial picture, missing important clues like  inflammation and scar build up. As a result, people with the same CKD stage are often labelled has having the same risk and are given the same treatments.

Dr McDonnell added: “This  discovery may will help doctors identify high-risk patients, so they enact more aggressive interventions, earlier specialist referral, and earlier treatment therapies.

“And by identifying low risk patients, they  would be able to prevent over-treatment.

“Living with chronic kidney disease often means managing fatigue, having limits to what you can and can’t eat, and being consigned to  frequent medical appointments.

“It can be physically and emotionally challenging, but with the appropriate care, it is possible maintain an active and fulfilling life.”

Plasma and Urinary KIM-1 in Chronic Kidney Disease: Prognostic Value, Associations with Albuminuria, and Implications for Kidney Failure and Mortality is published in   doi 10.1159/000547867is 

Biomarkers of kidney failure and all-cause mortality in chronic kidney disease  is published in the  DOI:10.1681/ASN.0000000767

The winner of this year’s Prize will be revealed on the evening of 1 October 2025, where they will be presented with a cheque for £25,000. Each of the five shortlisted authors will receive a cheque for £2,500.

A new study, led by researchers at The University of Manchester, in collaboration with Chester Zoo, found that birds appear to follow Zipf’s Law of Abbreviation (ZLA) – the idea that more frequently used sounds tend to be shorter. This rule, found in all human languages, helps make communication more efficient.

The findings, published in the journal today, offer new insight into how animals communicate and provide a new foundation for researchers exploring whether birds, like humans, shape their vocal signals according to the 'principle of least effort'.

Lead author Dr Tucker Gilman, Senior Lecturer at The University of Manchester said: “In human language, if we say something a lot, we tend to shorten it – like saying ‘TV’ instead of ‘television’. It turns out that the same pattern exists in birdsong.

“We know that birds and humans share similarities in the genes and brain structures involved in learning to communicate but this is the first time we’ve been able to detect a consistent pattern of ZLA across multiple bird species. There’s still a lot more work to be done but this is an exciting development.”

Although previous studies hinted that animal communication might follow ZLA – including in penguins – it has been difficult to find clear evidence of ZLA in birdsong. That’s partly because most birds have much smaller repertoires compared to humans. While humans use thousands of words, birds may only produce a few dozen distinct sounds.

To tackle this, the researchers developed new method for studying ZLA in birdsong that focuses on how often individual birds use certain note types and how long those notes last allowing them to examine communication at an individual rather than population level.

They then applied this method using a new open-source computational tool called ZLAvian, which compares real-world observed patterns to simulated ones to determine if ZLA is present.

Using ZLAvian, the team analysed more than 600 songs from 11 bird populations spanning seven different species. They found that while individual populations didn’t always show clear signs of ZLA, a stronger pattern emerged when the data was combined, showing more frequently used birdsong phrases were shorter on average.

Co-author Dr Rebecca Lewis, Conservation Scientist at Chester Zoo, said: “������ing ZLA in birdsong is far more complex than in human language. Birds often have very few note types, individuals even within the same species can vary widely in their repertoires, and classifying notes is tricky too. Our research has taught that it’s important to look across a wide range of species when looking for language patterns and we hope ZLAvian will make it easier for other researchers to explore these patterns in  more birds but also other animals in the future.”

The team says that further studies are needed across a broader set of bird species to confirm their findings.

Paper details:

Journal: PLoS Computational Biology

Full title: Does Zipf’s law of abbreviation shape birdsong?

DOI: 10.1371/journal.pcbi.1013228

Link:

The academics for the first time, identified how GPs in England are becoming less engaged with their work — and how these signs often follow one after the other, ultimately leading to the decision to quit.

The study published in and funded by the National Institute for Health and Care Research () School of Primary Care Research (SPCR) and Greater Manchester Patient Safety Research Collaboration (PSRC), helps explain the current GP workforce crisis.

While there is substantial evidence both internationally and within the UK of a growing exodus of GPs, until now we did not fully understand the warning signs or how they are linked.

Of 351 GPs from 57 practices surveyed via an online questionnaire, up to one in three GPs experienced symptoms of burnout (27%) and expressed a moderate to high intention to quit patient care within the next five years (33%).

Also from the study, one in five (19%) GPs reported low job satisfaction, two in five (41%) indicated poor work-life balance, and up to one in four (27%) reported working while unwell over the past year.

Further analysis showed that symptoms of burnout and low job satisfaction were the factors most directly linked to GPs’ intentions to leave their roles, even when other work-related factors were taken into account.

The findings suggest that burnout and job dissatisfaction are key drivers influencing GPs’ decisions to leave patient care within the next five years.

Other signs of work disengagement — such as working while unwell or having a poor work-life balance — were more indirectly linked to quitting, often through their effect on burnout and low job satisfaction.

Lead author Dr Christos Grigoroglou, a health economist from The University of Manchester, said:

“We found that job dissatisfaction and burnout are likely to be immediate signals that GPs are at high risk of quitting direct patient care. Poor work-life balance and working while unwell were also indirectly linked.

“This is why there is an urgent need to address these issues if we are to improve GP retention. If we do not, primary care may face unprecedented difficulties.”

The study authors suggested strategies including fair compensation, professional development, and a supportive work environment as ways to enhance job satisfaction.

Organisational support around time and resources to implement stress management programmes and mental health support could also help improve job satisfaction, reduce burnout, and retain GPs.

Preventative measures such as flexible working and fostering a supportive culture that encourages taking sick leave without stigma could improve work-life balance and reduce the tendency to work when unwell.

Principal investigator, psychologist Professor Maria Panagioti, said: “These findings highlight that GP retention policies should incorporate job satisfaction and wellbeing as core strategies to retain GPs.

“Additionally, improving work-life balance and reducing working while unwell can serve as effective early preventative measures to reduce burnout and job dissatisfaction — and in turn, help retain GPs.”

Associations between burnout and career disengagement factors among general practitioners: a path analysis is available

The University of Manchester has been awarded a major grant to lead a new programme that will transform the lifecycle of graphite in nuclear energy - an essential material for the future deployment of nuclear power.

The award brings together world-leading expertise led by The University of Manchester in collaboration with the Universities of Oxford, Plymouth, and Loughborough.

Nuclear energy is expected to play a central role in the UK’s net zero goals as it emits nearly zero carbon dioxide or other greenhouse gas emissions – but it comes with challenges.

The five-year ENLIGHT programme (Enabling a Lifecycle Approach to Graphite for Advanced Modular Reactors) will develop critical technologies to support the deployment of next-generation nuclear energy technology and will address two of the UK’s most pressing nuclear challenges - securing a sustainable, sovereign supply of nuclear graphite and finding solutions to manage the country’s growing volume of irradiated graphite waste.

The project is supported with an £8.2m grant from UK Research and Innovation’s Engineering and Physical Sciences Research Council (EPSRC), Higher Education Institutions, and around £5m of contributions from industry partners.

The programme of research, collaboration, and skills development aims to secure the UK’s position at the forefront of nuclear innovation and a global leader in advanced reactor technology and clean energy innovation.

Graphite is a critical component in many next-generation Advanced Modular Reactors (AMRs), including High Temperature Gas-cooled Reactors and various Molten Salt Reactor designs - technologies key to achieving the UK’s ambition to deliver 24GW of new nuclear power by 2050.

The material accounts for around one-third of reactor build costs, yet despite its importance, the UK currently relies entirely on imports to meet demand.

With the existing Advanced Gas-cooled Reactor fleet approaching decommissioning by 2028, and more than 100,000 tonnes of irradiated graphite already in storage, ENLIGHT will pioneer new approaches to both recycling legacy material and producing new, sustainable high-performance graphite suitable for future AMRs.

Dr Greg Black, Senior Advisor at the Environment Agency, said: “The Environment Agency look forward to participating as a partner in the ENLIGHT programme. As the environmental regulator for the nuclear industry in England, we consider the ambitions of the ENLIGHT programme on 'sustainable graphite' aligns with our Regulatory and RD&I areas of interest.”

The programme will focus on three strands of work:

• Sustainable Graphite – Developing processes for decontaminating, recycling and reusing irradiated graphite from AMR deployment.
• Graphite Selection & Design – Designing new graphite materials engineered to withstand extreme conditions in AMR environments.
• Graphite Performance – Understanding how these new materials behave in novel AMR conditions to improve its lifespan.

These advances could save the UK up to £2 billion in future waste management costs and offers a pathway to strengthen the UK’s unique position as a global hub for graphite research and innovation.

, Professor of Energy Materials at the University of Oxford will lead theme two around graphite selection and design. He said: “I’m delighted to be leading Theme two (Graphite Selection & Design – Designing new graphite materials engineered to withstand extreme conditions in AMR environments) in this major project.  Materials will contribute to several work packages across the whole activity, and our initial focus will be on novel studies of mechanical damage to support the design and qualification of new nuclear graphites for advanced fission reactors.”

At Loughborough University, researchers are contributing advanced computational modelling to explore how nuclear graphite behaves under extreme conditions.

Senior Lecturer in Materials Modelling at Loughborough University, said: “This will help us predict how and when these critical reactor components may fail, guiding the design of stronger, more reliable materials for the reactors of tomorrow. Our research also supports the reuse and recycling of existing graphite, helping to make future nuclear energy both safer and more sustainable."

The University of Plymouth will bring expertise in the analysis of porous materials, which will play a critical role in evaluating the performance and suitability of repurposed graphite.

, Lecturer in Environmental and Analytical Chemistry at the University of Plymouth, said: “This project is not just about scientific discovery; it's about pioneering sustainable solutions for nuclear energy, turning waste into a valuable resource and bolstering the UK's energy security for decades to come. This consortium embodies a truly cyclical and green approach to nuclear solutions, aiming for a cleaner energy transition and helping to demystify some of the traditional concepts that surround the nuclear industry. Our expertise in analysing the intricate properties of porous materials will be instrumental in ensuring the suitability of repurposed graphite for next-generation nuclear reactors, and we are particularly excited to have the opportunity to grow our relationship with The University of Manchester – and our industrial partners across the nuclear industry – through this initiative.”

ENLIGHT will also focus on skills development to expand the national graphite research community and train the next generation of graphite scientists and engineers essential to the UK's clean energy future.

Home to the and a core partner in the , The University of Manchester is uniquely positioned to lead the ENLIGHT programme. The University brings together cutting-edge facilities from the Irradiated Materials Laboratory and the .

ENLIGHT will also build on Manchester's role in flagship activities and initiatives including, the , the and

“Understanding how counter fraud work is carried out is important for improving its effectiveness," added Dr Benson. ”Our research will better understand the experiences of those delivering these services, identifying what challenges they face and what support they need. This insight is vital for shaping a more strategic and joined-up approach to tackling fraud across the NHS."

The research was a partnership with the International Institute for Applied Systems Analysis, and is published in the journal .

 

The study, published in journal Social & Cultural Geography, offers important lessons for researchers, policymakers and the public. By listening to how people make sense of their lives, especially during the long stretch of middle-age, we can better support their needs - and challenge the idea that middle-age is boring or unimportant.

Dianne said of the CATE recognition: "I feel truly privileged to have led the development and continued delivery of our PGCert programme. At the heart of our success is a team philosophy grounded in open dialogue, mutual respect, and trust—where every individual voice is valued. It's a genuine pleasure to work in an environment where collaboration and support are embraced by all, and I couldn't be prouder of what our team has achieved together."  

Bip added: “The PGCert team is truly unique in the way it functions, supporting colleagues to achieve their very best. I am delighted the team has been recognised for our excellence in collaborative working which showcases the very best of what teaching looks like when we truly work together for the flourishing of colleagues and learners.”  

The PGCert Medical and Health Education is offered through the University’s Transnational Education operation to expand its reach, value and impact, helping healthcare systems around the world and improving health outcomes for patients globally. 

Professor April McMahon, who was Vice-President for Teaching, Learning and Students at the time of the nominations, said: “Many congratulations to Ang, Jenni, Dianne, Bip and everyone who has supported them. The NTFs and CATE awards are highly competitive and prestigious, and it is wonderful to see that again our Manchester people have done so well. Our students, and those considering coming to join us in September, should also be encouraged that teaching excellence is such a focus for us at Manchester.”

The 2025 awards ceremony will take place on 25 September in Bristol, hosted by incoming Advance HE Chief Executive Alistair Jarvis.  

In the past, aid helped these countries avoid economic crises. But over time, aid became more about short-term goals like fighting poverty or improving health, and less about helping countries grow strong, independent economies. “We’ve forgotten that aid used to be about helping countries stand on their own two feet,” says Dr Behuria.

The research also takes aim at what’s called ‘Global Development’ - a newer idea that treats poverty in rich countries the same as poverty in poorer ones. While this sounds fair, Dr Behuria says it confuses the issue and weakens the case for giving aid to the countries that need it most. “Yes, there’s poverty in London and New York - but that’s not the same as poverty in Malawi or Bangladesh,” he explains.

Dr Behuria calls for a new way of thinking - what he terms a “structuralist” approach - where we tackle the deep, historical roots of inequality between nations. He says academics, governments, and the public all need to reconnect with the original purpose of aid: correcting global injustice.

"I hope to contribute to the growth of the institute, which has been phenomenal in the past 15 years, and help position the institute for the new challenges emerging around the world."

"The HCRI has always been known for its excellence in research and teaching, and for its policy-relevant work, engaging a multitude of stakeholders on the ground. I plan to build on this track record to further consolidate the HCRI's position in the UK, Europe and beyond as one of the key institutes to study and do research in humanitarian, disaster, global health and peace and conflict studies."

Professor Lemay-Hébert will lead an Institute at the forefront of research in humanitarian, conflict and disaster studies, as well as a thriving teaching unit at undergraduate and postgraduate levels. HCRI’s teaching portfolio includes a pioneering - and in the current times of global conflict, ever more important - joint degree programme in Humanitarian Practice, in collaboration with Médecins Sans Frontières and the Liverpool School of Tropical Medicine.

The project will run from September 2025 and is open to pupils aged five to 11 as part of their PSHE (Personal, Social, Health and Economic) education. Children will explore not only bereavement but other forms of loss – such as the death of a pet or a friend moving away – through archaeology-inspired art and poetry. Parents will be invited to information sessions and can choose whether their children take part. 

‘Lost and Found’ builds on the success of previous AHRC-funded projects, including ‘Continuing Bonds’ and ‘Dying 2 Talk’, which used archaeology to support conversations about death in secondary schools. The new pilot will result in a workshop resource pack for other schools to replicate the approach. 

This initiative also aligns with the UK Government’s recent inclusion of grief education in . 

‘Lost and Found’ builds on nearly £100,000 in AHRC funding and follows two earlier projects:  and . These initiatives explored how archaeology can support conversations about death, dying, and bereavement in non-medicalised, creative ways. 

Continuing Bonds brought together archaeologists, healthcare professionals, and psychologists to explore legacy and loss, while Dying 2 Talk co-produced resources with secondary school pupils, using artefacts and workshops to help young people reflect on grief and caregiving through the lens of the past. 

The study sets out clear recommendations for further improvements, based on direct community feedback. These insights are expected to inform future active travel strategies both locally and nationally.

The full report is available here: .

The study, published in Nature Physics, and carried out at ETH Zurich, demonstrates how researchers used a finely tuned laser and vacuum system to trap and cool a 100-nanometre glass disc composed of billions of atoms. The work sets a new benchmark for quantum purity, a measure of how closely a system behaves according to the rules of quantum mechanics. 

Dr. Jayadev Vijayan, a Research Fellow in the Department of Electrical and Electronic Engineering at The University of Manchester, explains: “This high-purity quantum state of motion gives us the best starting point to test whether objects 10,000 times heavier than the current record-holder show wave-like behaviour characteristic of the quantum world.” 

A new cold source for quantum experiments  

In the quantum world, atoms can behave like both particles and waves at the same time, appearing to being  “in two places at once” – an effect that only happens in the quantum world.  

To observe these effects in larger objects, their motion must be cooled close to absolute zero – where the only remaining motion is due to quantum fluctuations, the jittering of empty space itself. 

To achieve this for the first time, researchers used a laser beam to trap a nanoparticle and make it levitate inside a vacuum chamber. The vacuum chamber removes all the air, so nothing can bump into the particle and heat it up. Next, they placed the particle between two mirrors facing each other, forming a cavity to cool the motion of the particle. 

Professor Carlos Gonzalez-Ballestero, Institute of Theoretical Physics at TU Wien, explains: “The laser can either supply energy to the nanoparticle or take energy away from it. By carefully adjusting the cavity mirrors, we can make sure that the laser almost always takes energy away. The particle then spins slower and slower until it reaches the quantum ground state.” 

What makes this result remarkable is the record-breaking purity of the quantum state. High purity means the object is behaving in a way that is almost entirely quantum, with very little influence from the environment. That level of control and precision opens doors to experimental tests of quantum mechanics at completely new scales. 

Putting large quantum systems to use 

This breakthrough creates a pathway to revolutionary new technologies. The larger a quantum object is, the more sensitive it becomes to certain types of forces, potentially making them incredibly sensitive quantum sensors. For example, levitated nanoparticle-based sensors could provide: a new type of precise navigation system that does not need global satellite systems; early detection systems for earthquakes and volcanic activity; and mapping tools for subterranean topology. 

• This research was published in the journal Nature Physics. Full title: High-Purity Quantum Optomechanics at Room Temperature. DOI: 10.1038/s41567-025-02976-9 . Available

The team introduced a new type of thermal switch utilising high thermal conductivity graphite films. When a voltage is applied, ions insert between graphite layers. These ions disrupt phonon motion, cutting thermal conductivity by up to 1,300%. Removing the voltage expels the ions and restores the original heat-carrying capacity. This powerful modulation allows the device to actively turn heat conduction "on" and "off" at will, mirroring the functionality of electronic transistors, but for heat instead of electricity.

 “What makes our device truly transformative is its ability to operate reliably in extreme environments such as space,” said Dr Pietro Steiner, lead author and current technology lead for graphene-based thermal technologies at , a spinout from the University of Manchester. "The solid-state nature and absence of mechanical parts make it particularly attractive for aerospace applications, where reliability, weight, and efficiency are critical."

Beyond basic switching, the team demonstrated that their device could actively steer heat flow in desired directions. By configuring voltages across patterned electrodes, they created anisotropic thermal conduction pathways, opening possibilities for programmable thermal management systems.

Lead author added, "This thermal switching technology could revolutionise spacecraft thermal regulation, offering dynamic and reconfigurable solutions to manage excess heat without complex moving mechanisms or bulky radiators."

Spacecraft often rely on radiators or mechanical valves to dump excess heat. These systems add weight and risk mechanical failure under vibration. A thin, solid-state switch removes those constraints. It can operate in ultra-high vacuum and tolerate radiation levels found in orbit.

Next, the group will test switching speed under high thermal load. They plan to integrate the switch with prototype electronics. Faster ion motion and alternative intercalants could boost performance further. By directly linking electrical signals to heat transport, this work lays the groundwork for programmable thermal management in aerospace, electronics cooling and adaptive insulation.

This research was published in the journal .

Full title: Electrically controlled heat transport in graphite films via reversible ionic liquid intercalation

DOI: 10.1126/sciadv.adw8588

The is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field – a community of research specialists delivering transformative discovery. This expertise is matched by £13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

Silver has long been used to combat bacteria, particularly in wound care, due to its ability to release ions that disrupt bacterial cells. However, current approaches have limitations; silver can be released too rapidly or unevenly, potentially harming surrounding healthy tissue and resulting in short-lived or inconsistent antibacterial protection.

The Manchester team tackled these issues by designing a graphene oxide-based membrane that can release silver ions slowly and precisely over time. The key lies in the structure of the membrane itself, its nanoscale channels act like filters, regulating how much silver is released.

"Our research represents a paradigm shift in antimicrobial coating technology," states lead author . "By harnessing the potential of graphene oxide membranes, we've unlocked a method for controlled silver ion release, paving the way for sustained antimicrobial efficacy in various applications.”

The team also created a testing model that better reflects real biological conditions. By using foetal bovine serum in lab trials, they could simulate the environment the coating would encounter in the body, offering a clearer view of how it performs over time.

“This approach allows us to deliver just the right amount of silver for extended protection,” first author Dr Swathi Suran adds. “It has potential in many areas, including wound care dressings and antimicrobial coatings for implants, and could bring long-term benefits for both patients and healthcare providers.”

As the team looks ahead, they're focused on exploring how this coating could be integrated into a range of everyday and medical products, making bacterial resistance less of a hidden threat and more of a manageable challenge.

This research was published in the journal .

Full title: Tunable Release of Ions from Graphene Oxide Laminates for Sustained Antibacterial Activity in a Biomimetic Environment

DOI:

The National Graphene Institute (NGI) is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field – a community of research specialists delivering transformative discovery. This expertise is matched by £13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

The PDER was coordinated by the Policy Profession Unit, prepared for publication in the Department for Work and Pensions, and launched by the Cabinet Office with support from the University of the Arts London. 

The report represents a true cross-sector effort to rethink how government can better serve the public. Professor Richardson’s involvement highlights how academic research can directly shape public services, and help to build more responsive, trusted and inclusive government.

The manufacturing of African print textiles has shifted to China in the 21st century. While they are widely consumed in African countries – and symbolic of the continent – the rise of “made in China” has undermined the African women traders who have long shaped the retail and distribution of this cloth.

For many decades , the Dutch textile group which traces its origins to 1846 and whose products had been supplied to west Africa by European trading houses since the late 19th century, dominated manufacture of the cloth. But in the last 25 years dozens of factories in China have begun to supply African print textiles to west African markets. Qingdao Phoenix Hitarget Ltd, Sanhe Linqing Textile Group and Waxhaux Ltd are among the best known.

We conducted to establish how the rise of Chinese-made cloth has affected the African print textiles trade. We focused on Togo. Though it’s a tiny country with a population of , the capital city, Lomé, is the trading hub in west Africa for the textiles.

We conducted over 100 interviews with traders, street sellers, port agents or brokers, government officials and representatives of manufacturing companies to learn about how their activities have changed.

“Made in China” African print textiles are substantially cheaper and more accessible to a wider population than Vlisco fabric. Our market observations in Lomé’s famous Assigamé market found that Chinese African print textiles cost about 9,000 CFA (US$16) for six yards – one complete outfit. Wax Hollandais (50,000 CFA or US$87) cost over five times more.

Data is hard to come by, but our estimates suggest that 90% of imports of these textiles to Lomé port in 2019 came from China.

One Togolese trader summed up the attraction: “Who could resist a cloth that looked similar, but that cost much less than real Vlisco?”

Our research shows how the rise of China manufactured cloth has undermined Vlisco’s once dominant market share as well as the monopoly on the trade of Dutch African print textiles that Togolese traders once enjoyed.

The traders, known as Nana-Benz because of the expensive cars they drove, once enjoyed an economic and political significance disproportionate to their small numbers. Their political influence was such that they were key backers of Togo’s first – himself a former director of the United Africa Company, which distributed Dutch cloth.

In turn, Olympio and long-term leader General Gnassingbé Eyadéma provided policy favours – such as low taxes – to support trading activity. In the 1970s, African print textile trade was considered as significant as the phosphate industry – .

Nana-Benz have since been displaced – their numbers falling from 50 to about 20. Newer Togolese traders – known as Nanettes or “little Nanas” – have taken their place. While they have carved out a niche in mediating the textiles trade with China, they have lower economic and political stature. In turn, they too are increasingly threatened by Chinese competition, more recently within trading and distribution as well.

China displaces the Dutch

Dating back to the colonial period, African women traders have played essential roles in the wholesale and distribution of Dutch cloth in west African markets. As many countries in the region attained independence from the 1950s onwards, Grand Marché – or Assigamé – in Lomé became the hub for African print textile trade.

While neighbouring countries such as Ghana limited imports as part of efforts to promote domestic industrialisation, Togolese traders secured favourable conditions. These included low taxes and use of the port.

Togolese women traders knew the taste of predominantly female, west African customers better than their mostly male, Dutch designers. The Nana-Benz were brought into the African print textile production and design process, selecting patterns and giving names to designs they knew would sell.

They acquired such wealth from this trade that they earned the Nana-Benz nickname from the cars they purchased and which they used to collect and move merchandise.

Nana-Benz exclusivity of trading and retailing of African print textiles cloth in west African markets has been disrupted. As Vlisco has responded to falling revenues – over 30% in the first five years of the 21st century – due to its Chinese competition, Togolese traders’ role in the supply chain of Dutch cloth has been downgraded.

In response to the flood of Chinese imports, the Dutch manufacturer re-positioned itself as a luxury fashion brand and placed greater focus on the marketing and distribution of the textiles.

Vlisco has opened several boutique stores in west and central Africa, starting with Cotonou (2008), Lomé (2008) and Abidjan (2009). The surviving Nana-Benz – an estimated 20 of the original 50 – operate under contract as retailers rather than traders and must follow strict rules of sale and pricing.

While newer Togolese traders known as Nanettes are involved in the sourcing of textiles from China, they have lower economic and political stature. Up to 60 are involved in the trade.

Former street sellers of textiles and other petty commodities, Nanettes began travelling to China in the early to mid-2000s to source African print textiles. They are involved in commissioning and advising on the manufacturing of African print textiles in China and the distribution in Africa.

While many Nanettes order the common Chinese brands, some own and market their own. These include what are now well-known designs in Lomé and west Africa such as “Femme de Caractère”, “Binta”, “Prestige”, “Rebecca Wax”, “GMG” and “Homeland”.

Compared to their Nana-Benz predecessors, the Nanettes carve out their business from the smaller pie available from the sale of cheaper Chinese cloth. Though the volumes traded are large, the margins are smaller due to the much lower final retail price compared to Dutch cloth.

After procuring African print textiles from China, Nanettes sell wholesale to independent local traders or “sellers” as well as traders from neighbouring countries. These sellers in turn break down the bulk they have purchased and sell it in smaller quantities to independent street vendors.

All African print textiles from China arrive in west Africa as an incomplete product – as six-yard or 12-yard segments of cloth, not as finished garments. Local tailors and seamstresses then make clothes according to consumer taste. Some fashion designers have also opened shops where they sell prêt-à-porter (ready-to-wear) garments made from bolts of African print and tailored to local taste. Thus, even though the monopoly of the Nana-Benz has been eroded, value is still added and captured locally.

Since the COVID-19 pandemic, Chinese actors have become more involved in trading activity – and not just manufacturing. The further evolution of Chinese presence risks an even greater marginalisation of locals, already excluded from manufacturing, from the trading and distribution end of the value chain. Maintaining their role – tailoring products to local culture and trends and linking the formal and informal economy – is vital not just for Togolese traders, but also the wider economy.

, Reader, Global Development Institute, and , Postdoctoral fellow, Duke Africa Initiative,

This article is republished from under a Creative Commons license. Read the .

Approximately one in 50 people will develop wounds that fail to heal with the issue a particular problem for older people and in diabetes. 

Chronic wounds are more likely to become infected and can even result in a need for amputation making tackling them a really important issue. 

The paper published in the , reveals that the enzyme-  called arginase 1 -  can  promote wound repair in the  skin, through modulation of  a protein called Lipocalin2. 

A major factor in non-healing wounds is a failure of the damaged outer layer of skin, the epidermis, to repair and regrow. This can be worsened by uncontrolled inflammation and infection. 

The authors show that on wounding Arginase 1 enhanced production of Lipocalin2, an anti-microbial agent, which was required to combat infection and help the skin cells reform the skin barrier. 

Arginase 1 also reduced levels of inflammatory products made by the damaged skin cells showing its potential for tackling the inflammation typically associated with chronic wounds.

 The researchers also showed that the function of arginase, could be restored to help skin regrow by adding products that arginase 1 can make which include metabolites called polyamines. 

The paper follows on from previous by the team, published in February, which showed how important this enzyme Arginase 1 was for healthy skin and eczema. 

A healthy skin barrier involves a balance between cells multiplying (‘proliferating’) and changing their function (‘differentiating’). A key feature of eczema is a disruption of this balance. Arginase is required for skin barrier regulation where it functions to promote cell differentiation, a process essential to maintain a protective healthy skin barrier. A process that is disrupted in eczema.

 Arginase 1 has been shown to have an important role in tissue repair but how it promotes skin health was until now, unknown. 

Lead author Sheena Cruickshank, Professor of immunology at The University of Manchester ‘s Lydia Becker Institute of Immunology and Inflammation, said: “These two studies highlight the mechanism by which arginase 1 promotes barrier function and ensures good wound healing. 

“It’s importance is highlighted by the abnormal levels of Arginase seen in wounds that don’t heal well and eczema 

“That is why we think that targeting arginase 1 has potential to be used in the treatment of eczema and non-healing skin ulcers. Data in the two papers suggest it might also protect the skin from infection.” 

She added: “Non-healing skin wounds, or ulcers, are incredibly common and serious skin conditions that are more common as we age. 

“They can have a devastating effect on the lives of patients, causing chronic pain, problems with mobility and can lead to increased morbidity. 

“Similarly, eczema can significantly impact quality of life, leading to intense itching, pain, and sleep disruption. It can also increase the risk of skin infections. 

“We clearly have a long way to go before these skin conditions can be cured, but knowing the crucial role of arginase 1 in the healing process and that we can rescue function in model systems is an important milestone.” 

Jason Wong, Professor of Reconstructive Plastic Surgery and Regenerative Medicine  from The University of Manchester said: “The burden of chronic wounds seems to be on the increase and any new insights to how we can treat the problem will save limbs.” 

The PhD studentship for coauthor Denis Szondi was funded by the Agency for Science, Technology and Research (A*STAR) Singapore and The University of Manchester. 

The Biotechnology and Biological Sciences Research Council (BBSRC) funded a PhD studentship for co-author Rachel Crompton. 

Banked tissue collection was funded by Wellcome Institutional Strategic Support Fund and supported by the National Institute for Health and Care Research (NIHR)Manchester Biomedical Research Centre (BRC). (Prof Wong is part of the Dermatology Theme at the NIHR Manchester BRC.

British Journal of Dermatology, Volume 193, Issue 1, July 2025, Pages 125–135, 

The publication includes detailed chapters on iconic buildings such as Whitworth Hall, the John Rylands Library and Jodrell Bank’s Lovell telescope, as well as little known aspects of campus history including lost rivers, nuclear reactors, Toblerone-shaped halls of residences and unrealised plans for an underground station.

The book particularly highlights the architectural significance of Owens College, and how its Gothic Revival buildings designed by Alfred Waterhouse established a distinct identity in Victorian Manchester. These early structures set a tone of civic ambition and intellectual seriousness that still echoes through the campus today.

A dedicated section also explores the post-war expansion of science and engineering facilities at the University, driven by Cold War priorities and rising student numbers. It examines the rapid, often pragmatic construction of labs and lecture theatres, many of which defined the university’s mid-20th-century landscape.

“This book offers the public a chance to see behind the scenes - to understand why buildings were built the way they were, and how the campus continues to evolve to meet the needs of students, researchers and the wider city,” added Dr Hopkins.

The publication was made possible through the generous support of both internal and external partners. Within the University, from the School of Environment, Education and Development and the University of Manchester Library. Additional support was provided by companies that have worked closely on building projects across the campus over the years, including Avison Young, Arcadis, Balfour Beatty, BDP, CBRE, Halliday Meecham Architects, Recom Solutions, Rider Levett Bucknall, and Sheppard Robson.

Building Towards the Bicentenary is available to view for free .

Professor Devinney joins other Manchester-based Fellows including Professors James Nazroo, Melanie Giles and Penny Harvey, who have all been elected to the British Academy in recent years reflecting the University’s enduring commitment to cutting-edge scholarship and societal impact.

President of the British Academy Professor Susan J. Smith said: “One of my first acts as incoming President is to welcome this year’s newly elected Fellows, who represent the very best of the humanities and social sciences. They bring years of experience, evidence-based arguments and innovative thinking to the profound challenges of our age.”

“Every new Fellow enlarges our capacity to interpret the past, understand the present, and shape resilient, sustainable futures. It is a privilege to extend my warmest congratulations to them all.”

The team uncovered a rare type of wave, known as a shear phonon polariton, in a two-dimensional form of the material. Phonon polaritons are light-matter hybrid waves that emerge when light interacts with atomic vibrations in certain crystals. They can travel through materials in unusual ways and concentrate light into extremely small volumes.

In this study, the researchers found that in  thin films of gypsum, these waves undergo a topological transition, shifting from hyperbolic to elliptical behaviour, passing through a unique canalized state.

This transition allows scientists to tune how light propagates through the material.

“The studies of shear phonon polaritons in previous studies were limited to bulk crystals in the hyperbolic regime. In our study we aimed to complement those initial findings with shear polaritons in a 2-dimentional material,” said Dr Pablo Díaz Núñez, who co-led the study. “And remarkably, we discovered that shear phonon polaritons in gypsum support a topological transition from hyperbolic to elliptical propagation, with canalization in between.”

Dr Díaz Núñez added, “Moreover, we were able to confine light to a space twenty-five times smaller than its wavelength and slow it down to just a fraction of its speed in vacuum, this opens up new possibilities for manipulating light at the nanoscale.”

The research also highlights the role of crystal symmetry. Gypsum belongs to a class of materials with low symmetry, specifically to the monoclinic crystal system, which gives rise to asymmetric light propagation and energy loss, the central characteristic of shear polaritons.

These findings extend beyond fundamental research of phonon polariton propagation and could support future developments in areas that rely on precise control of light, such as thermal management, sensing, and imaging beyond the limits of conventional optics. Moreover, the study introduces gypsum as a new platform for exploring advanced photonic concepts in emerging areas like non-Hermitian photonics.

This research was published in the journal .

Full title: Visualization of topological shear polaritons in gypsum thin films

DOI:

The National Graphene Institute (NGI) is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field – a community of research specialists delivering transformative discovery. This expertise is matched by £13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

Professor Duncan Ivison, President and Vice-Chancellor of The University of Manchester also commented: “Lord Alliance was a close friend to the University and a remarkable figure whose contributions extended far beyond it. His belief in the transformative power of education created opportunities for generations of students, while his leadership and philanthropy shaped the Alliance Manchester Business School and the wider Manchester region. His story will remain a source of inspiration for years to come, and his legacy will endure in the lives he touched and the institutions he helped to build.”

The study, led by ETH Zurich and supported by The University of Manchester, sheds new light on how fast-moving mixtures of water, soil and rocks – known as debris flows – develop into a series of surges, destroying everything in their path. 

Using highly sensitive 3D laser scanners, the scientists collected measurements during a major debris flow in the Illgraben valley in Switzerland on 5 June 2022. Analysis enabled the scientists to pinpoint how small surface disturbances evolve down the channel into powerful large amplitude waves that concentrate the flow’s destructive power.

The findings, published in the journal , are among the most detailed measurements of a real-life debris flow ever recorded.

Debris flows are a recurring natural hazard in steep terrain throughout the world, and are triggered by heavy rainfall, and increasingly, glacial runoff and permafrost melt. Recent landslides in the Alps continue to highlight the risks posed by debris flows, such as the 2017 Bondo landslide in Graubünden, which triggered a debris flow that travelled 4km downhill into the Bondasca Valley. This emphasises the urgent need to better understand and predict these hazardous events.

Due to the frequency of debris flow occurence, the Illgraben valley has been equipped with measuring instruments since 2000. It has recently supplemented by five highly sensitive 3D laser scanners, called LiDAR, which can determine distance and speed, and six high-speed video cameras.

On the day of the June 2022 event, 25,000 cubic meters of water, earth and debris poured approximately seven kilometres down the bed of the Illbach before the muddy stream was absorbed by the river Rhône at Susten. The devices measured surface velocities and the evolving free surface of the debris flow at three measuring stations with a spatial resolution of 2 cm and a temporal resolution of 0.1 seconds.

The team of scientists from ETH Zurich, Swiss Federal Institute for Forest, Snow and Landscape Research (Birmensdorf) and The University of Manchester, were able to document how the waves grew along the channel and use the data to develop a new friction law that was used in a debris-flow model to realistically simulate the  genesis and growth of the waves.

They found that near the top of the (about 2km from the outflow into the Rhône river), the debris flow had a fast-moving wave front, but no surges, while further down the channel the flow became shallower and spontaneously developed a series of waves. During the 30-minute event, researchers recorded 70 of these surges, which emerge from a surface instability that allows the waves to grow and as they move downhill.

Lead researcher, Jordan Aaron, Professor of Engineering Geology at ETH Zurich, said: "It has long been known that waves play a central role in the destructive power of debris flows, because they concentrate the forces that are applied to structures in their path.

"Thanks to the measurements around the debris flow of June 2022 and the modelling based on them, the researchers now have a better understanding. Our analysis provides new insights into the dynamics of debris flows and enables improved hazard management in the medium term.”

This research, which was partially funded by the UK’s Natural Environment Research Council (), has been published in the journal Communication Earth & Environment

Full title: Detailed observations reveal the genesis and dynamics of destructive debris-flow surges

DOI: doi.org/10.1038/s43247-025-02488-7

Link:  https://www.nature.com/articles/s43247-025-02488-7

The research study was funded by the National Institute for Health and Care Research (NIHR), LifeArc and the Wellcome Trust and published in The Lancet Neurology today (16/07/25). 

Twenty-five years ago when Timothy Bingham was two years old, he had a mild flu like illness which left him unable to walk. 

Three years later following another infection, he was paralysed and has been in a wheelchair ever since. 

Then in 2011, doctors saw an 8-month-old girl at a UK hospital who had been completely fit and well until a mild chest infection left her unable to breathe without the support of a ventilator. 

They considered that there may be a genetic cause as her two brothers had experienced similar severe problems following mild infections. 

Genetic researchers at the University of Manchester have now discovered that changes in a gene called RCC1 led to this severe nerve damage in both Timothy and the family in Manchester. 

A further 20 children from 10 families from the UK, Türkiye, Czechia, Germany, Iran, India, Saudi Arabia, Cyprus, and Slovakia have been found to have changes in the same gene leading to this severe nerve condition all triggered by mild infections. 

In over half of the children, doctors suspected the diagnosis of a different severe nerve condition that can develop after infection called . 

The researchers performed laboratory studies on skin cells taken from patients and in specially genetically  engineered fruit flies to show that the damage to nerves can be caused by certain chemicals. 

Skin cells from patients when looked at under special microscopes have changes very similar to those seen in the cells of patients with motor neuron disease where muscles, including those controlling breathing and swallowing, become weak. 

Bill Newman, Professor of Translational Genomic Medicine at the University of Manchester and Rare Condition co-theme lead at the NIHR Manchester Biomedical Research Centre led the research. 

He said: “Until this study, little was known about why some people experience severe nerve damage after they have had a mild infection like flu or a stomach upset. 

“This work provides families with an explanation and is the first step in us developing an effective treatment. As children are well before they develop nerve damage following an infection, this gives us an opportunity to treat at risk children before problems occur. 

“The similarity with Guillain-Barré syndrome and with conditions like motor neuron disease may help us understand these more common conditions and why some people are at greater risk and what treatments may be effective.” 

Kate Bingham, mum of Tim who is now 28, said: “About 25 years ago Tim got a flu like infection and a temperature. What seemed like a minor illness had devastating consequences. 

“The attack, and subsequent attacks - did terrible damage. First to his legs, then his arms, his face and his chest. 

“And now he needs 24-hour care. His diaphragm barely works at all so he can’t cough. It’s hard for him to chew and he can’t drink unassisted. He can’t move in bed so needs turning throughout the night. The things we all take for granted he can’t do. 

“But I’m proud of how strong Tim has been. He now has a girlfriend he met online who is wonderful. He proves there is life beyond disability.” 

She added: “As Tim’s mum the discovery of a gene which is linked to what happened to Tim means everything to me. For so long we have lived with uncertainty of not knowing the full picture. 

“This breakthrough brings us great hope as it will do to all those people who have waited years for answers. This is something that helps us look to the future.” 

Sam Barrell, CEO of LifeArc, said, ““For many people living with rare conditions, the wait for a diagnosis can be agonisingly long - around a third wait more than five years. In Timothy’s case, that uncertainty stretched for over twenty years.  This discovery provides a potential target for treatment and the first step towards delivering a brighter future for people that could be living with this same devastating condition.” 

Image: Kate and Tim and Tim with his dog, Red.

The paper Acute-onset axonal neuropathy following infection in children with biallelic RCC1 variants: a case series is published in The Lancet Neurology here DOI 

The research, published today in , investigates a meter-long flipper from a Temnodontosaurus - a giant ichthyosaur – with uniquely preserved with fossilised soft tissues.

The findings reveal that the marine reptile, which exceeds 10m in length, was equipped with evolved to have specialised fins that the scientists believe served to suppress the sound of its own movements when foraging in dimly lit environments about 183 million years ago - an evolutionary adaptation never previously seen in any aquatic creature, living or extinct.

The team involves an international team of scientists, led by Dr Johan Lindgren from Lund University in Sweden, in collaboration with one of the world’s leading ichthyosaur experts, , a Palaeontologist at The University of Manchester, who has been working on the fossil for about six years and says the finding “represents one of the greatest fossil discoveries ever made”  and could revolutionise the way scientists investigate other prehistoric animals.

Dr Lindgren, who has pioneered research on ancient marine reptile soft tissues, said: “The wing-like shape of the flipper, together with the lack of bones in the distal end and distinctly serrated trailing edge collectively indicate that this massive animal had evolved means to minimise sound production during swimming. Accordingly, this ichthyosaur must have moved almost silently through the water, in a manner similar to how living owls—whose wing feathers also form a zigzag pattern—fly quietly when hunting at night. We have never seen such elaborate evolutionary adaptations in a marine animal before.”

Although many small ichthyosaurs have been found with soft-tissue preservation, scientists have never found anything on this scale.

Using a range of advanced imaging, chemical analysis and computational modelling techniques, the researchers also identified that the structure of the flippers were truly unique, with scalloped trailing edge reinforced by mineralised, rod-like structures that the team name ‘chondroderms’. 

Moreover, Temnodontosaurus also had the largest eyes – the size of footballs – of any vertebrate known, supporting the hypothesis that this aquatic reptile hunted under low-light conditions, either at night or in deep waters. 

Dr Dean Lomax, who is also an 1851 Research Fellow at the University of Bristol, said: “The first time I saw the specimen, I knew it was unique. Having examined thousands of ichthyosaurs, I had never seen anything quite like it. This discovery will revolutionise the way we look at and reconstruct ichthyosaurs (and possibly also other ancient marine reptiles) but specifically soft-tissue structures in prehistoric animals.”

 The fossilised flipper was discovered by fossil collector Georg Göltz, a co-author on the new study. Remarkably, Georg made the find entirely by chance whilst looking for fossils at a temporary exposure at a road cutting in the municipality of Dotternhausen, Germany.

The fossil consists of both the part and counterpart (opposing sides) of almost an entire front flipper. Although Georg looked for more, no other remains were found. As the top part of the fin is missing, the team surmise that it was originally an isolated flipper that might have been ripped off by a larger ichthyosaur.

Georg brought the specimen to the attention of palaeontologist and co-author Sven Sachs of the Natural History Museum, Bielefeld, who recognised the rarity of the find.

Dr Lindgren said: “The fact that we are able to reconstruct the stealth capabilities of a long-extinct animal is quite remarkable. Also, because human-induced noise from shipping activity, military sonar, seismic surveys, and offshore wind farms has a negative impact on today’s aquatic life, our findings could provide inspiration to help limit the adverse biological effects from anthropogenic input to the modern marine soundscape.”

 To unravel the mystery behind the features preserved in this fossil, it was subjected to a range of sensitive imaging, elemental and molecular analyses. The multidisciplinary research team included palaeontologists, engineers, biologists and physicists. This involved high-end techniques such as synchrotron radiation-based X-ray microtomography at the Swiss Light Source SLS at PSI and Diamond Light Source, time-of-flight secondary ion mass spectrometry and infrared microspectroscopy, along with the reconstruction of a virtual model using computational fluid dynamics.

Dr Lomax added: “The fossil provides new information on the flipper soft tissues of this enormous leviathan, has structures never seen in any animal, and reveals a unique hunting strategy (thus providing evidence of its behaviour), all combined with the fact that its noise-reducing features may even help us to reduce human-made noise pollution. Although I might be a little bias, in my opinion, this represents one of the greatest fossil discoveries ever made.”

The very first ichthyosaur brought to the attention of science was discovered over 200 years ago by pioneering palaeontologist Mary Anning and her brother Joseph. That fossil was also a Temnodontosaurus, the same type of ichthyosaur to which this flipper belonged.

“In a weird way, I feel that there is a wonderful full-circle moment that goes back to Mary Anning showcasing that even after 200 years, we are still uncovering exciting and surprising finds that link back to her initial discoveries”, added Dr Lomax.

Nature article reference: Lindgren, J., Lomax, D. R., Szász, R-Z., Marx, M., Revstedt, J., Göltz, G., Sachs, S., De La Garza, R. G., Heingård, M., Jarenmark, M., Ydström, K., Sjövall, P., Osbæck, F., Hall, S. A., de Beeck, M. O., Eriksson, M. E., Alwmark, C., Marone, F., Liptak, A., Atwood, R., Burca, G., Uvdal, P., Persson, P. and Nilsson, D-E. 2025. Adaptations for stealth in the wing-like flippers of a large ichthyosaur. Nature, 10.1038/s41586-025-09271-w.

Link to paper:

Up to £50 million is to be invested in a Medical Research Council Centre of Research Excellence (MRC CoRE) in Exposome Immunology over the next 14 years.

These environmental exposures, which also include things like microbes and toxins, predominantly interact with our bodies at what we call ‘mucosal barrier sites’, for example our lungs and intestines. Here, they met by our immune cells, and can change how the immune system works, pushing some tissues into chronic inflammation, causing diseases such as asthma, chronic obstructive pulmonary disorder (COPD) and inflammatory bowel disease (IBD).

The centre will embrace AI technology to interrogate large data sets, such as those from UK Biobank, patient cohorts and long-term studies in hospital clinics, and identify common pathways by which environmental factors disrupt the immune system. Findings will be tested through laboratory studies and by exposing healthy volunteers to pollutants and common viral infections, leading to more accurate diagnoses, better prevention, and more effective treatment options.

Individuals from disadvantaged socioeconomic backgrounds often have a more adverse exposome, facing greater exposure to pollution, mould (in poor quality housing), and occupational hazards (cleaning chemicals, industrial processes). The MRC CoRE is therefore key to The University of Manchester’s mission to address , and builds on work investigating .

Professor Judi Allen, from The University of Manchester is Director of the MRC CoRE in Exposome Immunology.

She said: “Globally we’re facing a crisis in chronic inflammatory diseases, such as asthma and inflammatory bowel disease. For decades we’ve been studying how our genes make us susceptible to disease. While very valuable, genetics has only got us so far. We need to understand how our environment interacts with our genes to make our immune system malfunction.”

“We will benefit from advances in new technologies to identify which of the many complex factors may be important in driving disease, but what’s different about our new Centre is we are going to define how the immune system is altered by these environmental factors and how that impacts inflammation. Changing environments, often made worse by socioeconomic disparities and rising pollution, appear to be increasing the rates of these diseases, making it even more imperative to find the causes.”

“We hope to later expand our research to include more environmental factors, such as mould and microplastics, which are growing concerns. An ultimate goal of this research would be to discover the underlying causes of these chronic diseases so we can develop better prevention and treatments.”

Professor Fiona Powrie, co-director of the MRC CoRE in Exposome Immunology, from University of Oxford, said: “This is an exciting opportunity to bring together complementary expertise in The University of Manchester and University of Oxford to build a multidisciplinary team to tackle this challenge. Our Centre will train a new generation of scientists working across biology and environmental science, future proofing our efforts to combat the health effects of a changing environment.”

Professor Patrick Chinnery, MRC Executive Chair, said: “This new MRC Centre of Research Excellence will transform our understanding of how lifelong environmental exposures shape immune health and cause chronic inflammatory diseases. With chronic inflammatory diseases posing such a large and growing disease burden, the new centre is well placed pave the way for more effective and targeted treatments.

“Alongside exceptional scientific leadership linking two world-leading centres, and strong partnerships with patients and digital health innovators, the scientists’ commitment to the next generation of researchers will embed UK leadership in this field, with long-term potential to deliver a transformative, global impact for health.”

The research, published today in the journal, , demonstrates that compounds or ‘volatiles’ found in sebum — the oily substance produced by our skin —hold key biomarkers for identifying Parkinson’s in its earliest stages.

Using a technique known as Thermal Desorption-Gas Chromatography-Mass Spectrometry (TD-GC-MS), scientists at The University of Manchester, in collaboration with Salford Royal NHS Trust and the Medical University of Innsbruck, analysed skin swabs from participants with Parkinson’s, healthy volunteers, and those with a sleep disorder called isolated REM Sleep Behaviour Disorder (iRBD) — a known early warning sign of Parkinson’s disease.

The results showed that people with iRBD had distinct chemical profiles in their sebum that were different from healthy individuals, but not yet as pronounced as those with established Parkinson’s disease. This supports the idea that Parkinson’s disease leaves a detectable trace on the body well before physical symptoms appear.

Joy Milne – the ‘super smeller’ who inspired the research  –  was also able to distinguish swabs from people with iRBD from the control group and Parkinson’s patients. Intriguingly, she was able to detect both diseases in two of the swabs that came from iRBD individuals, who were later diagnosed with Parkinson’s at their next clinical appointment, after sampling.

Professor Perdita Barran, Professor of Mass Spectrometry at The University of Manchester, said: “This is the first study to demonstrate a molecular diagnostic method for Parkinson’s disease at the prodromal or early stage. It brings us one step closer to a future where a simple, non-invasive skin swab could help identify people at risk before symptoms arise allowing for earlier intervention and improved outcomes.”

The study involved more than 80 participants, including 46 people with Parkinson’s, 28 healthy controls, and nine with iRBD.  They found 55 significant features in the sebum that varied between the groups. Those with iRBD often showed levels that sat between the healthy controls and the Parkinson’s group, reinforcing the possibility of detecting the disease in its early phase.

Dr Drupad Trivedi, a researcher from The University of Manchester, built a model that examined the markers in a longitudinal sampling study. He collected samples from Parkinson’s patients over a three-year period and found patterns that suggest this method can also be used to map the progression of the disease, which could have use in refining treatment options and improve patient outcomes.

Sebum is also easy to collect using gauze swabs from the face or upper back, making it ideal for non-invasive routine screening and regular monitoring. by the team has also shown it does not need to be stored in the same cold conditions as other biofluids, such as blood, reducing associated costs.

The research is inspired by the observations of Joy Milne, who detected a unique scent in individuals with Parkinson's disease, prompting researchers at The University of Manchester to explore sebum as a source of diagnostic biomarkers.

By using mass spectrometry, a technique that measures the weight of molecules, they have found that there are distinctive Parkinson’s markers in sebum, which has led them to develop this non-invasive swab test.

These findings have recently been validated in another paper, published today in the, where trained dogs were able to detect Parkinson’s in the patients recruited by Prof Barren and Dr Trivedi with remarkable accuracy by smelling skin swabs.

Now, the researchers are continuing to develop and improve the sebum-based testing to eventually use as a practical tool in real-world clinical settings.

Dr Drupad Trivedi, Lecturer in Analytical Measurement Sciences at The University of Manchester, said: "Our goal is to develop a reliable, non-invasive test that helps doctors detect Parkinson’s earlier, track its progression, and ultimately improve patient outcomes.

“We’re also keen to hear from other hyperosmic individuals, potential ‘super smellers’ like Joy, whose remarkable sense of smell could help extend our work to detect other diseases with potential odour signatures."

***

This research was published in the journal npj Parkinson's Disease

Full title: Classification of Parkinson’s Disease and idopathic REM Sleep Behaviour Disorder: Delineating Progression Markers from the Sebum Volatilome

DOI: 10.1038/s41531-025-01026-8

Link:

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Biotechnology is enabling us to find new and more sustainable ways to produce chemicals, materials, and everyday products, by understanding and harnessing nature’s own processes and applying them at industrial scales. Supported by the Manchester Institute of Biotechnology, our 400+ experts are innovating solutions in environmental sustainability, health and sustainable manufacturing. Find out more about our biotechnology research.  

The findings - based on the scans of 1,684 women - could make the difficult task of determining whether labour should be induced in the final stages of pregnancy easier, resulting in fewer complications, say the researchers.

Published today in the Lancet Obstetrics, Gynaecology and Women’s Health, the study was led by gynaecologist Sanne Gordijn of the University Medical Center Groningen (UMCG) in collaboration with Wessel Ganzevoort of Amsterdam University Medical Centre and Professor Alexander Heazell from The University of Manchester.

When pregnant women feel their baby is moving less in the final weeks of pregnancy, they are referred to hospital where an examination is carried out to assess the condition of the baby.

The examination consists of monitoring the baby’s heart rate and an assessment of its growth and amniotic fluid - the fluid around the baby it.

Now the researchers have discovered that an extra ultrasound scan - in addition to the other tests-  is able to significantly help doctors to see whether a baby would benefit from being born earlier.

By measuring the resistance in the blood vessels of the umbilical cord and the baby's brain they were able to accurately assess the functioning of the placenta and the condition of the baby, making it easier to decide if doctors needed to induce delivery earlier.

The perception from mothers that their baby is moving less commonly can occur when a baby has changed position or the mother hasn’t noticed the movement because she is busy or distracted.

However in some cases, reduced movement could be a sign that the baby is unwell, which can be worrying for pregnant women and midwives.

Professor Heazell said: “We know that a reduction in baby’s movements is a common reason to attend maternity services. Thankfully, in the majority of cases the baby is ok.

“The findings of this study will help us to reassure the majority of mothers that their baby is healthy, and help us to focus intervention for the babies who will benefit from being born because they are not receiving enough oxygen or nutrients in the womb.”

Sanne Gordijn said: “We call the ratio between the two ultrasound measurements the Cerebro Placental Ratio (CPR). The idea is that an abnormal value may indicate that the placenta is not functioning properly.

“In that case, it is better for the baby to be born in the short term. We do this by inducing labour. If the value is normal, it would be better to wait for the natural moment of delivery, as the baby may not be completely ready yet. Women who want to give birth at home can still do so.”

“The results of this study show better outcomes for the baby when the result of the CPR measurement is known.

“This means that we see fewer complications during childbirth when this measurement is taken, compared to the current policy where it is not done.”

She added: “If doctors know the results of this measurement, they can better distinguish whether the baby's reduced movement has a harmless cause or whether it requires action.

“This ensures that mother and baby receive the care that best suits their situation.' The guideline on reduced fetal movements will soon be updated; the professional association will incorporate the results of this study into it.”

The study was funded by ZonMw from the Netherlands.

Sanne Gordijn conducted this CEPRA study together with researchers from Amsterdam UMC in 23 hospitals. Laura Lens, the MD, PhD student on this study presented at the international SMFM conference in Denver (USA) and Sanne in London. The study is published on July 10 in the authoritative scientific journal The Lancet Obstetrics, Gynaecology & Women’s Health.

• The study is published in the Lancet Obstetrics, Gynaecology and Women’s Health and is available
• doi.org/10.1016/j.lanogw.2025.100002

Despite tearing his right knee ligament just eight weeks ago, the customer service officer – who works at a Halifax Housing Association – will walk 120 miles nonstop, without sleep.

Starting at the Angel of the North in Gateshead on Saturday 12 July, 42-year-old Ben will make his way to Tommy’s Rainbow Clinic and Maternal and Fetal Health Research Centre at Saint Mary’s Hospital – the specialist unit that helped save his son’s life.

Just seven days later, after flying to Rhodes, Ben will climb the steep mountain road to Prophet Elias Monastery in Faliraki, Greece an exhausting 50 times – a gruelling test of endurance with no shade and where temperatures are likely to soar above 40°C.

Ben is aiming to raise £20,000 for Professor Alex Heazell, Director of the Tommy’s Stillbirth Research Centre and the University of Manchester-based team leading UK research to reduce preventable stillbirths and support families through pregnancy after loss.

Ben and his partner Gaynor Thompson lost their daughter Kallipateira to a preventable stillbirth at 37 weeks in October 2018. They later suffered a miscarriage in 2019.

Determined to stop other families going through the same heartbreak, they founded The Kallipateira Moorhouse Foundation, which funds research and supports families affected by baby loss.

In 2020, their son Apollon was born safely at Tommy’s Rainbow Clinic, thanks to the specialist care of Professor Heazell.

Ben has since taken on multiple extreme solo fundraising feats.

“This year has brought mountains I’ve had to climb emotionally and physically. Now, I’m preparing to put myself through the mill – fuelled by love, grief, and purpose,” said Ben.

“There’s no pain greater than holding your dead baby in your arms – but every step I take will honour Kallipateira and help save other babies across the UK. I will once again show that because of love and a reason why, anything is possible.”

Every day in the UK, eight babies are stillborn – many of which are preventable.

The funds Ben raises will go directly to Professor Heazell’s team, who are making groundbreaking progress in understanding stillbirth and supporting parents in pregnancy after loss.

Alex Heazell, who is also Professor of Obstetrics at The University of Manchester and Honorary Consultant Obstetrician at Saint Mary’s Hospital, part of MFT, said: “Ben’s unwavering commitment is extraordinary. His support has already helped us improve care for families and expand our research into stillbirth prevention. These challenges will fund new projects that could save lives.”

Dignity Funerals, through Lawrence Funeral Directors Halifax, are proud headline sponsors of Ben’s 2025 challenge.

Stuart Cox, Head of Public Affairs at Dignity, said: “Ben is a true inspiration. We’re honoured to support The Kallipateira Moorhouse Foundation and the vital work they do in memory of Kallipateira.”

To support Ben’s Mission donate now at: 

The University of Manchester project has been awarded the grant through the NHS Cancer Programme Innovation Open Call with support from SBRI Healthcare (Small Business Research Initiative) as part of a new, unique national partnership which could save lives and improve quality of life.

Researchers in Manchester will implement an innovative lung cancer risk assessment tool and an adapted care pathway for Hodgkin lymphoma survivors, supported by the National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre (BRC).

The new multi-centre study started in June 2025 and will be running for two years within the existing NHS Lung Cancer Screening Programme at 10 Cancer Alliances across England, including Greater Manchester Cancer Alliance leading the initiative.

Every year, around 2,100 people in the UK are diagnosed with Hodgkin lymphoma, a cancer that develops in the lymphatic system (part of the immune system).

Although it is a highly curable cancer, treatments such as chemotherapy and radiotherapy to the chest and lungs increase the risk of second cancers occurring in later life. This risk increases further for people who smoke.

Survivors of Hodgkin lymphoma are six times more likely to develop lung cancer than the general population.

������ lead Dr Kim Linton, Senior Lecturer at The University of Manchester and Living With and Beyond Cancer Co-Theme Lead at Manchester BRC, said: “It is crucial that Hodgkin lymphoma survivors can access screening to detect lung cancer at an early stage, when it is more treatable.”

Developed in Manchester, the new UK-wide programme aims to screen 500 Hodgkin lymphoma survivors over two years, which could detect early lung cancer in an estimated 10-12 people.

Joanne Murray, from Didsbury in Manchester, was diagnosed with Hodgkin lymphoma in 1997 at the age of 29 and received successful treatment at The Christie NHS Foundation Trust.

She took part in the pilot study in 2022 which helped Manchester researchers design the new national programme. Despite having no symptoms, the study found Joanne had stage 1 lung cancer.

Now 56 and living in North Wales, Joanne said: “I feel exceptionally lucky that this research has saved my life. I had no symptoms of lung cancer and had I not taken part in this study, it might have been too late for me once symptoms had appeared.”

Through the study, Joanne had a CT scan at The Christie in Manchester which revealed a ‘fluffy’ and opaque nodule (small lump) on her right lung. Following surgery to remove part of her lung, a biopsy revealed it was stage 1 cancer.

Joanne, who works for North Wales Police, explained: “After my scan, doctors closely monitored me through ‘watch and wait’, with regular check-ups to determine if the nodule grew or if I developed symptoms. In November 2023, after I had moved to Wales, a follow-up scan at my local hospital showed that the nodule had grown by 1mm. After discussing my treatment options, I decided to have surgery to remove part of my right lung.”

Joanne had the surgery in January 2024 at Liverpool Heart and Chest Hospital. She said: “I was absolutely terrified of having the surgery, but it was fine, and all the staff were fantastic. I had video-assisted thoracoscopic surgery [a form of keyhole surgery] which was less invasive, and I was back home in two days to recover.

“When I found out from the biopsy that it had been stage 1 cancer, I was in complete shock. I’m a positive person and thought I had just been overthinking it. I am so thankful for this vital research and the team at The Christie.”

Now 18 months later, Joanne has had two clear scans, with the next one due in early 2026.

On taking part in research, Joanne said: “When I read the letter asking me if I wanted to be part of research I thought, ‘there’s nothing wrong with me, but I’ll do it.’ You never know what’s around the corner.

“Without doubt, I would urge other cancer survivors to take part in screening. It might take 10 or 15 minutes out of your day, but it could save your life.”

Hodgkin lymphoma can develop at any age, but it mostly affects people between 20 and 40 years of age and those over 75. The most common symptom is a painless swelling in a lymph node, usually in the neck, armpit or groin.

Second cancers, such as lung cancer or breast cancer, can develop more than 10 years after treatment for Hodgkin lymphoma. Survivors can help to reduce their risk of a second cancer by adopting a healthy lifestyle through not smoking, maintaining a healthy weight with a balanced diet, and getting regular exercise.

Dr Linton, who is also an Honorary Consultant in Medical Oncology at The Christie NHS Foundation Trust, said: “Most Hodgkin lymphoma survivors do not meet current lung cancer screening criteria, so we hope the success of this study will support an application for routine adoption across England and Wales.

“In Manchester, we have been working on a lung cancer screening programme for Hodgkin lymphoma survivors for many years, including a pilot screening study at The Christie where we detected 3 lung cancers in 102 people who had showed no symptoms.

“This research helped us to design the national programme and confirmed that our proposed study meets the needs of this high-risk patient group. This work also builds on Manchester’s previous track record of successfully implementing breast cancer screening for Hodgkin lymphoma survivors within the national breast cancer screening programme.”

The new study will be open to Hodgkin lymphoma survivors aged between 45 and 74 who smoke or have previously smoked.

It will have an embedded programme to identify and tackle health inequalities, including people where their risk of lung cancer is highest, such as those with lower socioeconomic status, men and older people.

It will help address barriers to screening participation, such as fear of cancer diagnosis, low perceived risk of cancer and issues of cost, travel and time off work.

Screening will take place at convenient community-based settings to encourage participation, including in mobile clinics at supermarket car parks.

Researchers will actively promote screening participation for people with the highest smoking prevalence.

Participants will be offered health education and stop smoking advice to encourage supported self-management to prevent lung cancer, cardiovascular disease and other significant illnesses, which could lead to improved survivorship and reduced healthcare costs.

The Manchester-based project is part of the NIHR Manchester BRC’s , which aims to transform the detection of cancer recurrence and second cancers to improve quality of life and treatment outcomes for survivors.

Researchers will also be collaborating with the NIHR Manchester BRC’s , which aims to reduce cancer burden across society through implementing prevention and early detection strategies.

The project will be supported by the NIHR Oncology Translational Research Collaboration, Lymphoma Action charity and patient partners.

Health Innovation Manchester will work with Greater Manchester Cancer Alliance to support local adoption and run patient focus groups to understand barriers to engagement and develop solutions to improve uptake.

• images: Dr Kim Linton and  Joanne and Rob

The former GP, Director of Public Health and Medical Director was tragically killed in a terrorist attack while holidaying in Sri Lanka. 

She studied medicine at The University of Manchester and started her medical career as a GP in Salford. 

Her brother Lord Keith Bradley will today (9/07/25) present this year’s prize to Mark Westwood, who received a distinction at the 13th International of Public Health. 

Mark, who has worked in the NHS and volunteered with the Scouting movement is hoping to join the University as a PhD student. 

Lord Keith Bradly – a Labour Party politician created the award in his sister’s name to recognise highest achieving Masters in Public Health (MPH) student from Greater Manchester. 

Prof Arpana Verma, Programme Director of the MPH said: “Sally was an inspiration to us all. Not only was she a remarkable clinician and public health doctor, she was a wife, sister, aunt, friend and colleague to countless many. 

“She was kind, clever and incredibly knowledgeable. She lit up the room with her charisma, charm and her infectious laugh. 

“There are no words to express our gratitude to Lord Bradley and Sally’s amazing family to honour our programme and our students with this inspirational award.” 

She added: “As we teach and train the next generation, we can give our students and alumni the incredible legacy Sally has left us. 

“Mark is a worthy recipient of this honour. He has been an exceptional student and will go on to make important contributions to the field of public health. 

“His voluntary work has been exceptional -  and signifies just how much he cares about the community in which he lives 

The Masters in Public health online programme, created in 2002 by Prof Dick Heller, was was one of first fully distance learning programmes in the UK. 

Since then it has grown to over 2,000 alumni from all over the world, offering fully flexible learning options to allow students to juggle working full time with their studies.

Lord Bradley said: “On behalf of my family, I am proud to pay tribute to my sister, Dr Sally Bradley, who was so cruelly killed alongside her husband Bill in the Easter Day bombings in Sri Lanka some 5 years ago. 

“Since that time, I have recovered numerous messages of kindness remembering Sally and conversations with many of her former colleagues and friends who stressed how inspirational she was to their careers and her utter commitment to preventative healthcare and the crucial role of public health in that endeavour. 

“I am delighted that Mark Westwood will receive this year’s Dr Sally Bradley prize. He clearly encapsulates the values that my sister tried to instil in public health in Manchester and well beyond. He is a tremendously worthy winner. 

“I and my family are honoured to ensure that Sally’s legacy will live on and that we all continue to strive for improved health and wellbeing throughout our communities.” 

Students can to learn the ‘art and the science’ of public health at their own pace, with a choice of over twenty different course units covering what professionals need for their careers in public health both here and internationally. 

The course concentrates on research-led teaching and students are encouraged to participate and learn from research partners and projects, especially for their dissertations. 

The themes of this year’s festival are AI and In-Silico Public Health, Women’s research and Inclusive Research. 

• More information on the Masters in public Health programme is available here
• Image is of Sally Bradley.

Professor Richard Grencis was given the honour for his sustained commitment to the advancement of immunology, leading to significant changes in our understanding of how the immune system works. 

The scientist has been based at The University of Manchester since In 1987 when he was appointed lecturer in immunology at the School of Biological Sciences. He became professor of immunology in 1998. 

Professor Grencis is also academic lead at the University’s Biological Services Facility, and has been a scientific member of the University of Manchester Animal Welfare Ethical Review body (AWERB) for many years. 

He has pioneered the study of immunity to parasitic infection, some of the most prevalent infections on earth and responsible for much debilitating disease and ill-health. 

Of all the types of parasite, roundworms (nematodes) which live in the gastrointestinal tract are the most common, with in excess of one and a half billion people currently infected. 

He said: “I am delighted to receive this award and grateful for the recognition it gives to this crucial area of research.

 “Our studies focus on defining the regulation of the immune response to roundworm infections which live in the gastrointestinal tract. 

“There is an urgent need to tackle this problem: millions of people living in low and middle income countries, especially children, have to contend with the terrible problems caused by roundworm parasites. 

“There are currently no vaccines for these parasites in humans and a deeper understanding of how the immune system deals with roundworms helps us towards this goal. 

“An added bonus is that our studies have also helped us make new fundamental discoveries of how the immune system works. 

“Much progress has been made in this area, but there is still a long way to go.”

Professor Cox returned to his hometown of Oldham in July for a series of four inspirational ‘Great Horizons’ events. These celebrated STEM education and highlighted the vital role teachers and industry play in shaping future opportunities for young people in Oldham. They were designed to raise the profile of science teachers and science learning, towards igniting ambition in the next generation of scientists, engineers, and innovators.  On Tuesday 1 July, Professor Cox took part in a celebration event for science teachers and leaders from across Oldham’s schools. The event was coordinated by the Cranmer Trust and brought over 250 teachers together to identify how they can take science to a new level in their schools. 

The following day, he engaged with primary school pupils in a ‘tour of the galaxy’ during special morning assemblies, promoting participation in the Great Science Share for Schools. 

In the afternoon, Professor Cox met with business leaders, council representatives, and local influencers, working with Oldham’s Economy Board’s and Oldham Athletic Football club with the remit to lever local business engagement to actively support education and career pathways in STEM. 

Later that evening, he hosted a Q&A session with secondary and college students at Oldham Sixth Form College, sharing insights and answering questions about science and space. 

 The University of Manchester provided leadership in coordinating and hosting the events, with special focus on the primary school event that involved Professor Cox having a whistle-stop tour of 4 primary schools in Oldham, working to ignite the curiosity of hundreds of pupils. Across the town other schools received VIP visits from the Oldham Lord Mayor, industry and charity professionals. These experiences provided opportunity to incentivise schools to become involved in the University’s  flagship campaign, the Great Science Share for Schools, which celebrated its 10th anniversary this year. The campaign encourages young people to ask, investigate and share scientific questions, elevating the prominence of practical science in the classroom. 

Professor Lynne Bianchi, FSE Vice Dean for Social Responsibility, Equality, Diversity and Inclusion, and Director of SEERIH, said: “The two days were powerful in bringing the town’s industry and education partners together. It’s been a real place-based approach that is starting something that will have legacy beyond these launch events. The key now is to harness the energy that spued out of each event and identify key actions that can impact on young people in the short and longer term.’  

Dave Benstead, Chairman of Oldham Enterprise Trust and Oldham’s Economy Board, said: “We set out to optimise STEM-Industry-School-College partnerships which will lead to greater exposure of a variety of STEM career options, broaden student's perspectives and help them make more informed decisions as they progress through education. Our young people need a clearer understanding of the real-world problems that STEM related careers can address and Professor Brian Cox achieved this grabbing their interest and motivation as only he can.” 

With acknowledgments to: Oldham Council, Oldham Enterprise Trust, Oldham Athletic Football Club, Cranmer Education Trust, Pinnacle Learning Trust and SEERIH (The University of Manchester). 

Using high-resolution 3D seismic (sound wave) imaging, combined with data and rock samples from hundreds of wells, researchers from The University of Manchester in collaboration with industry, identified vast mounds of sand – some several kilometres wide – that appear to have sunk downward, displacing older, lighter and softer materials from beneath them.

The result is stratigraphic inversion - a reversal of the usual geological order in which younger rocks are typically deposited on top of older ones on a previously unseen scale.

While stratigraphic inversion has previously been observed at small scales, the structures discovered by the Manchester team – now named “sinkites” – are the largest example of the phenomenon documented so far.

The finding, in the journal Communications Earth & Environment, challenges scientists understanding of the subsurface and could have implications for carbon storage.

Lead author Professor Mads Huuse from The University of Manchester, said: “This discovery reveals a geological process we haven’t seen before on this scale. What we’ve found are structures where dense sand has sunk into lighter sediments that floated to the top of the sand, effectively flipping the conventional layers we’d expect to see and creating huge mounds beneath the sea.”

It is believed the sinkites formed millions of years ago during the Late Miocene to Pliocene periods, when earthquakes or sudden shifts in underground pressure may have caused the sand to liquefy and sink downward through natural fractures in the seabed. This displaced the underlying, more porous but rigid, ooze rafts - composed largely of microscopic marine fossils - bound by shrinkage cracks, sending them floating upwards. The researchers have dubbed these lighter, uplifted features ‘floatites’.

The finding could help scientists better predict where oil and gas might be trapped and where it’s safe to store carbon dioxide underground.

Prof Huuse said: “This research shows how fluids and sediments can move around in the Earth’s crust in unexpected ways. Understanding how these sinkites formed could significantly change how we assess underground reservoirs, sealing, and fluid migration — all of which are vital for carbon capture and storage”.

Now the team are busy documenting other examples of this process and assessing how exactly it impacts our understanding of subsurface reservoirs and sealing intervals.

Prof Huuse added: “As with many scientific discoveries there are many sceptical voices, but also many who voice their support for the new model. Time and yet more research will tell just how widely applicable the model is.”

This research has been published in the journal Communications Earth & Environment

Full title: Km-scale mounds and sinkites formed by buoyancy driven stratigraphic inversion

DOI:

Celebrating its 10^th anniversary this year, the campaign inspires teachers of 5-14 year olds to upskill their own knowledge and skills of teaching science enquiry - a form of science education that gives the pupils the opportunity to explore a scientific question through practical investigations linked to .  

Using innovative resources and ideas related to this year’s theme of #ConnectedScience, pupils across the UK and across the world have been taking the lead and becoming science communicators.  The theme illustrates how science is not isolated in learning, but rather, the way we think scientifically has the power to connect our ideas and successes in all areas of our lives. 

The campaign runs throughout the year, leading to registrations from 835,135 pupils sharing on or around Tuesday 17 June. With wider reach across the globe, #GSSfS inspires teachers and educators from 52 different countries to take part, with events taking place across venues such as schools, hospital schools, museums, sports venues and universities.  

This year, The University of Manchester hosted more than 35 schools from across Greater Manchester in its Nancy Rothwell building.  

Some of the questions shared this year included: 

• Are all flowers the same? 
• How does wind speed affect voltage generated? 
• Which type of soil will retain the most water to help keep plants hydrated in hot weather? 
• How does the temperature of the ocean affect coral? 

The GSSfS campaign was launched by Professor Lynne Bianchi, Vice Dean for Social Responsibility at The University of Manchester, to provide a unique way to elevate the prominence of science in the classroom, focussing on learner-focussed science communication, inclusive and non-competitive engagement, and promoting collaboration.  

Professor Bianchi, said: “It’s been truly inspiring to witness the Great Science Share for Schools reach its 10th anniversary with such global momentum.”

In 2024 and 2025, the campaign was granted the prestigious patronage of the , in recognition of its status as a beacon of excellence in science education and its pivotal role in shaping the next generation of scientists, innovators, and global citizens.  

Now in its 10^th year, the GSSfS strategy further develops to explore strategic alliances with ministries of education and schools across the world.  This year the Ministry of Education in Malta and the STEM & VET Curriculum and the Museo de Ciencias Universidad de Navarra in Spain, and the Foundation for Education and Development (FED) Unified Learning Centre in Khao Lak, Thailand have become a key focus for development. 

Grace Marson, Campaign Manager, said: “What Great Science Share for Schools has shown year on year, is that pupils have a thirst for science. They are naturally curious about the world around them and given the opportunity through GSSfS, they demonstrate that they can ask amazing scientific questions. This campaign puts pupils at the centre of their learning.”  

By carefully monitoring the level of cancer activity in the blood, doctors can identify the best time to start and stop the drugs to give treatment breaks, which it is hoped will prevent resistance to treatment developing and also reduce side effects. This experimental blood test could help people with stage 4 melanoma, a type of skin cancer, live longer. 

The ground-breaking approach looks for tiny fragments of DNA coming from the cancer, which can be found in the patient’s blood. 

Dr Rebecca Lee, consultant oncologist and clinician scientist at The Christie and a senior lecturer in Medical Oncology at The University of Manchester is leading on the DyNAMIc trial.She said: “Cancer treated with targeted therapy can be thought of as two armies of cells; those that are sensitive to the treatment and those that are resistant, which fight for nutrients in order to grow. A patient does not want either cell army to win as that means their cancer will get worse. Although the targeted therapy can kill the sensitive cells, over time the resistant ones grow through. However, if treatment breaks are given, it is thought that the growth of these resistant cells can be suppressed by the sensitive cells. 

“This blood test enables us to develop a new approach to overcome resistance to targeted therapy treatment. The DyNAMIc trial is really at the forefront of precision medicine. We can adapt the treatment in response to the patient’s melanoma activity levels in real-time and therefore reduce the chance of the cancer becoming resistant in the long term.  This could be a real game-changer in how we treat melanoma and other patients with cancer undergoing similar treatments in the future.” 

Professor Paul Lorigan, consultant oncologist at The Christie and chief investigator for the DyNAMIc trial said: “Evaluating new biomarker in clinical trials such as DyNAMIc allows us to personalise treatment decisions and continue to improve outcomes for patients with melanoma and other cancers.  The close collaboration between The Christie and the National Biomarker Centre has allowed us to take this from concept to clinical trial.  The study is now open in ten centres in the UK, led by the Manchester team. This would not be possible without support from the patients and their families, The Christie and The Christie Charity, Jon Moulton Charity Trust, Cancer Research UK and many other colleagues.” 

Dr Dominic Rothwell, the Deputy Director of the Cancer Research UK National Biomarker Centre and one of the team who helped develop the test said: “The DyNAMIc trial is a great example of how cutting-edge research, funded by the Jon Moulton Charity Trust and CRUK can lead to the development of exciting new tests and how, in close collaboration with our clinical colleagues, these tests can be transferred to the clinic and lead to the potential improvement of treatments for cancer patients.” 

The first patient to join this clinical trial was a supermarket worker from Stockport in Greater Manchester. Jan Smith (64) had been working on the shop floor at her local superstore in November 2022 when she started to experience severe pain and was rushed to A&E. A scan revealed kidney stones which doctors were able to treat successfully.  However, the scan also showed a shadow near her left kidney which was far more serious. It was a 12-inch-deep mass around her adrenal gland at the top of her kidney and a biopsy confirmed she had stage 4 (the most advanced stage) melanoma in December 2022. 

The self-confessed ‘crazy cat lady’, who shares her home with five much-loved moggies, was referred to The Christie. 

“I hadn’t had any symptoms and never take time off sick at work. The pain I had with the kidney stones was unbelievable. Like nothing I’d known before. But in a strange way they saved my life.” Jan explained: “It was good news to be told that they had managed to clear the stones but a real shock to discover I had cancer. My local hospital said they couldn’t remove the tumour as it was too big, so I was referred to The Christie for more specialist treatment.” 

In January 2023 Jan began a course of immunotherapy, which uses the body’s own immune system to fight the cancer. Unfortunately, within weeks her condition worsened, and she developed speech difficulties and weakness on one side of her body. Jan was given the devastating news that she had developed two brain tumours and needed emergency life-saving surgery to remove part of the tumour in the right side of her head. 

Unfortunately a scan in October 2024 found a new growth near Jan’s liver so she was offered the chance to participate in research at the ) at in Manchester. Jan was told in the November she was eligible for DyNAMIc, a clinical trial which aims to improve how well the treatment works for patients whose melanoma can’t be removed by surgery or has spread. 

Jan was prescribed two targeted drugs, encorafenib and binimetinib which is an approved treatment in patients with melanoma. They suppress a protein called BRAF, which causes melanoma cells to survive and grow. Around half of people with melanoma have a BRAF mutation which can become overactive.  

These drugs stop the cancer growing and can shrink the tumour by killing off the cells with the abnormal gene. But the cancer can fight back and develop more changes and become resistant to the treatment. Therefore, a sensitive blood test which precisely measures the amount of circulating DNA from the cancer enabling treatment can be turned on and off as required could be very beneficial to patients. 

Talking about her experience of being on the clinical trial, Jan Smith said: “This has been quite a journey with one thing after another, and my battle with cancer is certainly not over yet.  Despite numerous setbacks and changing treatments, I’ve tried to always stay positive and I’m glad to be benefiting from this trial.

“I am pleased to take part in research. If we don’t try new treatments, then we’ll not get the answers and make the medical advancements we need.”

The DyNAMIc study is open for recruitment with the aim of recruiting 40 participants.  The trial is funded by the Jon Moulton Charity Trust, sponsored by The Christie and run by the Liverpool Clinical Trials Centre.  

According to Cancer Research UK, new treatments for melanoma have improved outcomes in recent years. Around half of people with stage 4 melanoma can now survive for 10 years or more.

Dr Rebecca Lee is a senior lecturer in Medical Oncology at The University of Manchester and her post at The Christie is funded by .

Any patients interested in taking part in clinical trials should discuss this option with their consultant or GP. Not all patients will fit the criteria for a specific trial. While clinical trials can be successful for some patients, outcomes can vary from case to case. More information about taking part in clinical trials can be found .

To date, over 2000 patients have consented to be part of the ID LIVER study, with more than 600 assessed in community settings across Greater Manchester over the last year, as part of the . 

This research project is delivered as part of a series of projects that looks to address Greater Manchester’s major diseases for the Advanced Diagnostics Accelerator (ADA), part of the . The Accelerator has been established to rapidly improve the diagnosis and treatment of disease across the 2.8m Greater Manchester population.

Stephanie Landi, Clinical Research Hepatology Fellow at Manchester University NHS Foundation Trust (MFT), said: “ID LIVER is shifting the focus of liver disease care towards early detection and intervention. By bringing liver health assessments directly into communities, we are removing barriers to access and reaching people who might otherwise present much later with advanced disease. We also know that liver disease disproportionally impacts those living in areas of high socioeconomic deprivation, so by targeting these communities, we are ensuring care reaches those who need it the most. Early detection empowers individuals to understand their liver health and make informed decisions before complications develop.”


Health Innovation Manchester met with Tony, aged 68 from Greater Manchester, who attended the Early Detection of Liver Disease (ID LIVER) health check in his locality, following a referral from his General Practitioner (GP). 

Tony decided to act on this referral after meeting the criteria for the screening opportunity and followed up before an appointment was made for him. He explained that he was pleasantly surprised that the health-check was so easily accessible for him:

“An appointment was made for me… I turned up and it was all very pleasant, there was no stress, no worry – I just turned up, did the test which was a scan, and that was it. The opportunity is there and there are people out there who want to help you, it’s all being done to help you. It’s all about you, the patient.

“The thing for me, is that it’s done in my locality, it’s within walking distance… the way this is being done, this is the beauty of it, you’re just there and it’s all about you. It’s intimate really and it makes life easier. If you take the opportunity to get screened and get looked at, you’re cutting out a load of possible aggravation in the future.”

ID Liver participants are benefiting from state-of-the-art Greater Manchester Research Van - operated by MFT. The purpose-built vehicle is unique to the region with the goal of widening opportunities for people to be part of research in easy-to-reach locations, improving the relevance and quality of the research. as well as being more inclusive for members of the public.

Oliver Street, Programme Manager, Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine and Health at The University of Manchester, said: “Early detection and prevention of liver disease is extremely important because often symptoms do not present until the disease is advanced and damage to the liver is irreversible. By identifying and assessing patients at increased risk of liver disease we are supporting patients in receiving the right treatment at the right time and developing improved pathways of care.”

Daniel Zamora, Programme Director – Health Innovation Accelerator at Health Innovation Manchester, said: “This project is another fantastic example of how a targeted approach for early detection and community screening is having a lasting positive impact on the treatment of disease for people across Greater Manchester. Through the Accelerator we’ve now seen a considerable number of patients tested and screened for some of our region’s most prevalent diseases. This work will continue to help us shape how we can identify and treat patients moving forward with the use of innovative solutions across primary, secondary and community care settings

Israel’s recent surprise attack on Iran was ostensibly aimed at neutralising Iran’s nuclear programme, but it didn’t just damage nuclear installations. It killed scientists, engineers and senior military personnel.

Meanwhile, with no ties to the government or military, became “collateral damage”. For 11 days, Israel’s attacks intensified across Tehran and other major cities.

When the US joined the attack, dropping its bunker-buster bombs on sites in central Iran on June 21, it threatened to push the region closer to . Israel’s calls for regime change in Iran were joined by the US president, Donald Trump, who took to social media on June 22 : “if the current Iranian Regime is unable to MAKE IRAN GREAT AGAIN, why wouldn’t there be a Regime change??? MIGA!!!”

Trump’s remarks are reminders of past US interventions. The threat of regime change by the most powerful state in the world carries particular weight in Iran, where memories of foreign-imposed coups and covert operations remain vivid and painful.

In the early 1890s, Iran was after the shah granted a British company exclusive rights to the country’s tobacco industry. The decision was greeted with anger and in 1891 the country’s senior cleric, Grand Ayatollah Mirza Shirazi, issued a fatwa against tobacco use.

A mass boycott ensued – even the shah’s wives reportedly gave up the habit. When it became clear that the boycott was going to hold, the shah cancelled the concession in January 1892. It was a clear demonstration of people power.

This event is thought to have played a significant role in the development of the revolutionary movement that led to the that took place between 1905 and 1911 and the establishment of a constitution and parliament in Iran.

Rise of the Pahlavis

Reza Shah, who founded the Pahlavi dynasty – which would be overthrown in the 1979 revolution and replaced by the Islamic Republic – rose to power following a British-supported coup in 1921.

During the first world war, foreign interference . In 1921, with British support, army officer Reza Khan and politician Seyyed Ziaeddin Tabatabaee . Claiming to be acting to save the monarchy, they arrested key opponents. By 1923, Reza Khan had become prime minister.

In 1925, Reza Khan unseated the Qajars and , becoming Reza Shah Pahlavi. This was a turning point in Iran’s history, marking the start of British dominance. The shah’s authoritarian rule focused on centralisation, modernisation and secularisation. It set the stage for the factors that would that eventually lead to the 1979 Revolution.

In 1941, concerned at the close relationship Pahlavi had developed with Nazi Germany, Britain and its allies once again intervened in Iranian politics, . He was exiled to South Africa and his 22-year-old son, Mohammad Reza, in his place.

The 1953 coup

Mohammad Mosaddegh became Iran’s in 1951. He quickly began to introduce reforms and challenge the authority of the shah. Despite a sustained campaign of destabilisation, Mossadegh retained a high level of popular support, which he used to push through his radical programme. This included the , which was effectively controlled by the Anglo-Persian Oil Company – later British Petroleum (BP).

In 1953, he was ousted in a and placed under house arrest. The shah, who had fled to Italy during the unrest, returned to power with western support.

Within a short time, Mohammad Reza Shah Pahlavi established that governed through repression and intimidation. He outlawed all opposition parties, and numerous activists involved in the oil nationalisation movement were either imprisoned or forced into exile.

The 1979 revolution: the oppression continues

The shah’s rule became increasingly authoritarian and was also marked by the lavish lifestyles of the ruling elite and increasing poverty of the mass of the Iranian people. Pahlavi increasingly relied on his secret police, the Bureau for Intelligence and Security of the State.

Meanwhile, a scholar and Islamic cleric named Ruhollah Khomeini, had been rising in prominence especially after 1963, when Pahlavi’s unpopular land reforms mobilised a large section of society against his rule. His growing prominence brought him into confrontation with the government and in 1964 he was sent into exile. He remained abroad, living in Turkey, Iraq and France.

By 1978 a diverse alliance primarily made up of urban working and middle-class citizens had paralysed the country. While united in their resistance to the monarchy, participants were driven by a variety of ideological beliefs, including socialism, communism, liberalism, secularism, Islamism and nationalism. The shah fled into exile on January 16 1979 and Khomeini returned to Iran, which in March became an Islamic Republic with Khomeini at its head.

But the US was not finished in its attempts to destabilise Iran. In 1980, Washington backed Saddam Hussein in initiating a , which claimed hundreds of thousands of Iranian lives and severely disrupted the country’s efforts at political and economic reconstruction.

Iran and the US have remained bitter foes. Over the years ordinary Iranians have suffered tremendously under rounds of US-imposed , which have all but destroyed the economy in recent years.

This new wave of foreign aggression has arrived at a time of significant domestic unrest within Iran. Since the protests, which began in September 2022 after the death of Mahsa Amini at the hands of the morality police, there has been a general groundswell of demand for social justice and democracy.

But the convergence of external aggression and internal demands has brought national sovereignty and self-determination to the forefront, as it did during previous major struggles. While world powers gamble with Iran’s future, it is the Iranian people through their struggles and unwavering push for justice and democracy who must determine the country’s future.

, Senior Lecturer in Sociology,
This article is republished from under a Creative Commons license. Read the .

“This research provides a clear roadmap for change, underscoring that where a young person lives really matters,” said co-author Dr Emma Thornton. “Policymakers should prioritise proactive, upstream investments in affordable housing, improving local green spaces, and boosting accessible community support schemes. These interventions can make a tangible difference, helping to prevent mental health issues before they escalate and reducing long-term burdens on vital services.”

In the first ever study of its kind, tennis fan Dr Liam Blything analysed the impact of timeouts using from the world’s top 250 players between 2013 and 2023. 

Players at this year’s Wimbledon Championships will be watching closely how their opponents take a bathroom break, in light of the study. 

The paper follows years of speculation by journalists and sports people that the practice amounts to gamesmanship, bestowing an advantage for players taking a bathroom break by disrupting the rhythm of their opponent. 

However, proponents of the bathroom break argue that timeouts are a useful and acceptable way to help players reset.

 In response, the Association of Tennis Professionals (ATP) introduced a rule for the 2022 season to restrict timeouts to a maximum of 3 minutes, alongside limitations on when and how often they can be deployed. 

Published in the peer reviewed International Journal of Performance Analysis in Sport, Dr Blything found that 71% of time outs were taken when a player lost the previous set. 

And in normal circumstances, 33% of players recover the next set after losing the previous one. This, however, rose to 47% if they took a bathroom break. 

The data analysed by Dr Blything showed there were 1,928 breaks in play in the study period, though when medical and other breaks were accounted for, he was left with 366 bathroom timeouts. 

Dr Blything said: “There has been much argument in the media over recent years about the formalisation of gamesmanship in tennis, with the taking of bathroom breaks. 

“This study for the first time used real data to check the validity of those concerns. 

“There is now clear evidence a well-timed bathroom break in play confers an advantage to the player taking the break by regathering him or herself and disrupting the flow of the opponent..” 

Dr Blything also carried out follow up analyses on the extent to which unforced-errors contributed to the forms of points won and lost. 

The overall decrease in the opponent’s winner-shots was offset by an equivalent decrease in the strategist’s unforced errors, preserving the proportion observed in the baseline data. 

That showed timeout advantage is a combination of both the strategist benefitting from the opportunity to personally reset, and a disruption of the rhythm of the opponent, rather than being disproportionally driven by one player. 

Psychological theory also supports the notion that taking a break can confer advantages by interrupting momentum. 

Theorists argue an interruption disrupts perceptions associated with positive momentum for players who are on a roll, which is in turn difficult to regain. 

The timeout also potentially affords the opportunity for a losing player to refocus from that negative thinking spiral about prospective outcomes, for example by using self-talk and mental imagery techniques. 

Dr Blything added: “These pioneering findings uniquely inform players and tennis governing bodies about the influence of timeouts and, more broadly, elucidate the role that stoppages can play in sport for altering momentum. 

“It would be useful understand if this effect is relevant  in other sports. Snooker players, for example, seem to take a lot of bathroom breaks.” 

Examples of comments from players:

Andy Murray on a Stefanos Tsitsipas bathroom break after Murray won the 4th set 2-2 in the 2021 US Open 1st round. He went on to lose 3 - 2. “It’s just disappointing because I feel it influenced the outcome of the match. I’m not saying I necessarily win that match, for sure, but it had influence on what was happening after those breaks.”

Roger Federer who took a bathroom break after losing the 4th set 2-2 in the 2017 Australian Open semifinal. He went on to beat Wawrinka 3-2. “I think they're more mental than anything else. I only really did take the timeout because I thought, 'He took one already, maybe I can take one for a change'. Because I'm not a believer in any way that we should be allowed to take a lot of timeouts. But I took it after the set break. People know I don't abuse the system. I hope it's going to stay that way in the future for me, too.’

Stefanos Tsitispas, who’s opponent Novak Djokovic took a bathroom break after losing 2nd set to make it  0-2 in the 2021 French Open Final. Djokovic recovered to beat Tsitsipas 3-2: “I don't think I changed much, I just kept the same pace. I kept the things that were working for me. He left the court after two sets to love down, and he came back to me like a different player suddenly. I don't know. I have no idea.”

On the same match, Djokovic said: “The bathroom break was the turning point. Sometimes in these kind of circumstances where not much is happening positively for you on the court in terms of tennis and the other guy on the court is dominating the play, sometimes these things are necessary. A little break, a little pep talk, and try to recuperate and re-gather the thoughts and reassemble everything that you have and [counter] your opponent with the best possible game.  Maybe it's the experience, maybe it's the toilet break, maybe it's everything combined, but I'm just glad I'm through.”

The paper psychological (ab)use of timeouts in professional tennis is available DOI: 10.1080/24748668.2024.2436271:

The excavation of the site by Amgueddfa Cymru – Museum Wales and Heneb – The Trust for Welsh Archaeology and the careful lifting of the chariot grave components has revealed tanatalising glimpses of its potential: a rich suite of decorated chariot gear and weaponry, interred with someone who lived through the Roman conquest of Wales, and was buried in a moment of dramatic ritual. 

Whilst we know of many isolated artefacts and even hoards containing chariot gear, this find is currently the only complete chariot known from Wales - and also the ‘last’ chariot burial known from northern Europe, making this an internationally important find. 

This once-in-a-lifetime discovery now needs archaeological investigation and conservation to preserve and display these finds for the people of Pembrokeshire and Wales. Working with local organisations and school groups, particularly rural, traveller and conflict-migrant communities based in west Wales, the project will shape the story of the charioteer through an exciting programme of creative workshops and public performance events, alongside a three-year programme of conversation-led research into the finds and the burial site.

Led by Professor Melanie Giles from The University of Manchester, the project will draw on the skills of Iron Age curator Adam Gwilt and his expert conservation and curatorial team at Amgueddfa Cymru, alongside members of Heneb: Dyfed Archaeology, who were all involved in the original excavation. A workshop and public conference will help launch and celebrate this discovery, learning from other chariot discoveries in Britain, Ireland and the near Continent, such as the recent stunning Iron Age hoard finds from Melsonby (North Yorkshire). 

The results will then be used by expert chariot maker and wheelwright, Robert Hurford, to construct two full-sized chariot reconstructions – one to test in the field and use at public events, the other to display as part of an exhibition at both Oriel y Parc (St Davids) and St Fagans: National Museum of History. The whole process will be recorded as a film with many other resources hosted through the project website. A key theme of the project and the Welsh curriculum is cynefin – how knowledge of places and their past can deepen senses of belonging – and the team will host a special workshop with Welsh teachers to help shape new resources for schools in Pembrokeshire and beyond. 

This ambitious partnership project draws together Welsh heritage, community and creative partners as contributors. Cadw (Welsh Government’s historic environment body responsible for the care and protection of Wales’s cultural heritage) is a funding partner, while Pembrokeshire Coast National Park Authority will be an event and exhibition host at its Oriel y Parc, St David’s and Castell Henllys reconstructed Iron Age village venues. Heneb – The Trust for Welsh Archaeology will contribute staff expertise to help craft the final publication of the site in its regional setting whilst PLANED (the Pembrokeshire-based community-led social enterprise charity) will help co-design and deliver the public engagement programme, alongside the stunning creative skills of Pembrokeshire based Span Arts.  

Adam Gwilt, the Co-project Lead at Amgueddfa Cymru – Museum Wales said: ‘This unique chariot discovery has wonderful potential to captivate, inspire and engage with communities, helping us to tell rich new stories about Iron Age peoples living in western Britain at the time of the Roman invasion. This project, and our grant funding news, is a great success story for Amgueddfa Cymru, for our partners and for archaeology in Wales. I am really pleased that the team’s dedication and efforts so far, and in coming together to create this distinctive and collaborative project, have been recognised at UK level. It is really exciting that we can now begin to present this national treasure together in many ways, exploring meanings, connections and community responses, past and present.’

John Ewart, of PLANED said: ‘PLANED has been supporting communities for almost forty years and we are honoured to be working alongside so many culturally significant organisations on this incredible find. We are eager to be part of the next chapter in the story of the chariot and its location.’

Bethan Touhig-Gamble, Director of SPAN Arts said: ‘SPAN Arts is thrilled to be part of this exciting project, using creativity to connect the community to this important work.’

Richard Nicholls, Chief Executive of Heneb – The Trust for Welsh Archaeology said: ‘We were delighted to work in partnership with Amgueddfa Cymru, Cadw and the National Lottery Heritage Fund to excavate the first Celtic chariot burial site to be found in Wales. This new funding will ensure there is wider recognition of the importance of the find and we hope it will inspire future generations to connect with our shared heritage.’

Kathryn Roberts, Chief Inspector of Ancient Monuments and Historic Buildings, Cadw said: ‘We are delighted to support this project to learn more about the Pembrokeshire chariot burial and share its fascinating discovery more widely.   This project combines the specialist skills of archaeologists and conservators with craftsmen and storytellers in a unique mix that will explore the world of the charioteer and help people of all ages learn more about the life in Iron Age Wales.’ 

James Parkin, Director of Nature and Tourism at the Pembrokeshire Coast National Park Authority commented: ‘We are thrilled to be playing an integral part in this incredible partnership project showcasing the history, culture and rich archaeological legacy of this internationally important discovery. The project provides an opportunity for a diverse cross-section of Pembrokeshire communities to be involved in co-creating the stories linked to the charioteer, to deepen their connection, understanding and sense of place. We’re extremely pleased that Castell Henllys Iron Age Village, the only Iron Age site in Britain reconstructed on the exact site where our ancestors lived 2,000 years ago, will play a part in recreating the rich tapestry linked to this exciting discovery. We look forward to working together with partners to host the Cynefin exhibition at Oriel y Parc, National Park Discovery Centre in St Davids, showcasing the culmination of the project’s extensive research, engagement and creative collaborations.’

The five-year multi-centre research project – supported by £10mn funding from Wellcome – involves researchers from the Universities of Cambridge, Kent, Manchester, Oxford, and Imperial College London. SynHG is led by Professor Jason Chin of the MRC Laboratory of Molecular Biology; he was also recently announced as the founding Director of the Generative Biology Institute at the Ellison Institute of Technology, Oxford, and a Professor at the University of Oxford.

A dedicated social science programme, led by Professor Joy Zhang of the Centre for Global Science and Epistemic Justice at the University of Kent, runs throughout the project alongside the scientific development. The programme will work with civil society partners around the world to actively explore, assess and respond to the socio-ethical implications of tools and technologies developed by SynHG.

The benefits of human genome synthesis to research and beyond 
Since the completion of the Human Genome Project at the start of the century, researchers have sought the ability to write our genome from scratch. Unlike genome editing, genome synthesis allows for changes at a greater scale and density, with more accuracy and efficiency, and will lead to the determination of causal relationships between the organisation of the human genome and how our body functions. Synthetic genomes have the potential to open up brand new areas of research in creating targeted cell-based therapies, virus-resistant tissue transplantation and extensions may even enable the engineering of plant species with new properties, including the ability to withstand harsh climate. 

To date, scientists have successfully developed synthetic genomes for microbes such as E. coli. The field of synthetic genomics has accelerated in recent times, and advances in machine learning, data science and AI showing promise, with synthesised DNA becoming more widely available. However, today’s technology is not able to produce large, more complex sections of genetic material, such as found in crops, animals and humans. 

The research team are focusing on developing the tools and technology to synthesise large genomes exemplified by the human genome. Focusing on the human genome, as opposed to other model organisms such as mice, will allow researchers to more quickly make transformative discoveries in human biology and health.

 Professor Jason Chin, Founding Director of the Generative Biology Institute at EIT, Oxford, said: “The ability to synthesize large genomes, including genomes for human cells, may transform our understanding of genome biology and profoundly alter the horizons of biotechnology and medicine. With SynHG we are building the tools to make large genome synthesis a reality, and at the same time we are pro-actively engaging in the social, ethical, economic and policy questions that may arise as the tools and technologies advance.  We hope that Wellcome’s support for this combination of approaches will help facilitate substantive societal benefit.”

A bold, ambitious project facing complex scientific challenges 
SynHG focuses on developing the foundational tools and methods required to equip more researchers in the future. This research journey will potentially catalyse new technologies in the field of engineering biology, generating exciting discoveries about how cells use their genomes even before achieving complete genome synthesis. 

The team of researchers hope to provide proof of concept for large genome synthesis by creating a fully synthetic human chromosome, which makes up approximately 2% of our total DNA. Initially, the team hope to establish methods where small changes are made to the sequence of a chromosome with minimal onward effect on the proteins that it produces. 

Setting the foundation – testing the concept, iterating the methods, and embedding ethical considerations – could alone take many years. Even as engineering biology technologies improve, reliably building a complete synthetic human genome and meaningfully applying it to human health will likely take decades.

Michael Dunn, Director of Discovery Research at Wellcome, said: “Our DNA determines who we are and how our bodies work and with recent technological advances, the SynHG project is at the forefront of one of the most exciting areas of scientific research. Through creating the necessary tools and methods to synthesise a human genome we will answer questions about our health and disease that we cannot even anticipate yet, in turn transforming our understanding of life and wellbeing.” 

Professor Patrick Yizhi Cai, Chair of Synthetic Genomics at the University of Manchester said: "We are leveraging cutting-edge generative AI and advanced robotic assembly technologies to revolutionize synthetic mammalian chromosome engineering. Our innovative approach aims to develop transformative solutions for the pressing societal challenges of our time, creating a more sustainable and healthier future for all."

Embedding global socio-ethical discussions in scientific advancements 
To effectively translate scientific ambition into meaningful and potentially profound societal benefits, it is essential that there is proactive and sustained engagement with the evolving socio-ethical priorities and concerns of diverse communities. 

Wellcome is also funding Care-full Synthesis, a dedicated social research initiative conducting empirical studies with diverse publics worldwide. Led by Professor Joy Y. Zhang and hosted by the Centre for Global Science and Epistemic Justice (GSEJ) at the University of Kent, the project builds on GSEJ’s global network of academic, civil society, industry and policy partners to promote a new approach of science–society dialogue that is Open, Deliberative, Enabling, Sensible & Sensitive, and Innovative (‘ODESSI’). 

Professor Joy Zhang, Founding Director of the GSEJ at the University of Kent said: “With Care-full Synthesis, through empirical studies across Europe, Asia-Pacific, Africa, and the Americas, we aim to establish a new paradigm for accountable scientific and innovative practices in the global age—one that explores the full potential of synthesising technical possibilities and diverse socio-ethical perspectives with care.” 

Over the next five years, the team will undertake a transdisciplinary and transcultural investigation into the socio-ethical, economic, and policy implications of synthesising human genomes. The project places particular emphasis on fostering inclusivity within and across nation-states, while engaging emerging public–private partnerships and new interest groups. 

Through the generation of rich empirical data, the team will develop a toolkit to enable effective integration of careful thinking into the management, communication, and delivery of human genome synthesis. This work aims to substantially expand the practice of accountable science and innovation, reflecting the complex realities of a hyperconnected yet ideologically fragmented world. Care-full Synthesis will achieve this by advancing a fresh approach to engaging with global communities, ensuring that fast-moving science is accompanied by robust social and legal deliberation, and identifying innovative strategies to co-ordinate regional and global governance accounting for diverse social priorities and scientific pathways.

Designed by the undergraduate Physics Society, the sculpture is based on the telescope’s original engineering blueprints, ensuring a high level of accuracy and detail. Student James Ruxton spent six months perfecting the design using computer software to model and test different structures, producing a 4,000-page instruction manual. He even custom-designed some Lego pieces, using a 3D printer to create bespoke bricks. 

James and fellow Physics Society members began building the sculpture in late April. The finished model weighs 30kg, with 12.5kg attributed to the dish alone. Due to its weight, the dish had to be reinforced with a steel pole—mirroring a real-life engineering challenge faced during the telescope’s original construction eighty years ago. 

The sculpture serves as a tribute to the University’s pioneering role in astrophysics and engineering. It will be on permanent display in the Schuster Building, housed in a specially modified cabinet alongside a Lego model of a Large Hadron Collider detector—built by students a decade ago. 

A unique feature of the sculpture is a brick which was signed by Dame Jocelyn Bell Burnell - the physicist who discovered Pulsars - during her visit to the University to deliver this year’s annual Bragg Lecture in March.  

The sculpture arrives in time to commemorate the 80th anniversary of Jodrell Bank, a site of immense significance to The University of Manchester and to science in the UK.  

Professor Chris Parkes, Head of the Physics and Astronomy department, has been supporting the students with their project. He reflected: “Jodrell Bank has always been a symbol of bold innovation - pushing the boundaries of science and engineering from its earliest days.  

In December 1945, physicist Bernard Lovell travelled from Manchester to a quiet field in Cheshire hoping to explore the use of radar in cosmic ray detection. Instead, this became the start of the Physics Department's world-famous Jodrell Bank radio astronomy observatory.  

Over the following 12 years, Lovell and his team constructed the telescope that now bears his name. Its global importance was confirmed in 1957 when it became the only instrument capable of tracking the rocket carrying Sputnik 1, launched by the Soviet Union during the Space Race.  

Since then, the Lovell Telescope has stood at the forefront of astronomical research. In 2019, the Jodrell Bank Observatory was granted UNESCO World Heritage status, further cementing its legacy as a beacon of scientific innovation.